Parallel evolution of Batesian mimicry supergene in two Papilio butterflies, P. polytes and P. memnon

Takuro Iijima, Rei Kajitani, Shinya Komata, Chung-Ping Lin, Teiji Sota, Takehiko Itoh, Haruhiko Fujiwara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Batesian mimicry protects animals from predators when mimics resemble distasteful models. The female-limited Batesian mimicry in Papilio butterflies is controlled by a supergene locus switching mimetic and nonmimetic forms. In Papilio polytes, recent studies revealed that a highly diversified region (HDR) containing doublesex (dsx-HDR) constitutes the supergene with dimorphic alleles and is likely maintained by a chromosomal inversion. In the closely related Papilio memnon, which exhibits a similar mimicry polymorphism, we performed whole-genome sequence analyses in 11 butterflies, which revealed a nearly identical dsx-HDR containing three genes (dsx, Nach-like, and UXT) with dimorphic sequences strictly associated with the mimetic/nonmimetic phenotypes. In addition, expression of these genes, except that of Nach-like in female hind wings, showed differences correlated with phenotype. The dimorphic dsx-HDR in P. memnon is maintained without a chromosomal inversion, suggesting that a separate mechanism causes and maintains allelic divergence in these genes. More abundant accumulation of transposable elements and repetitive sequences in the dsx-HDR than in other genomic regions may contribute to the suppression of chromosomal recombination. Gene trees for Dsx, Nach-like, and UXT indicated that mimetic alleles evolved independently in the two Papilio species. These results suggest that the genomic region involving the above three genes has repeatedly diverged so that two allelic sequences of this region function as developmental switches for mimicry polymorphismin the two Papilio species. The supergene structures revealed here suggest that independent evolutionary processes with different genetic mechanisms have led to parallel evolution of similar female-limited polymorphisms underlying Batesian mimicry in Papilio butterflies.

Original languageEnglish
Article numbereaao5416
JournalScience Advances
Volume4
Issue number4
DOIs
Publication statusPublished - 2018 Apr 18

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Papilio
parallel evolution
butterflies
genes
genetic polymorphism
alleles
genomics
phenotype
repetitive sequences
transposons
predators
gene expression
loci
genome

ASJC Scopus subject areas

  • General

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Parallel evolution of Batesian mimicry supergene in two Papilio butterflies, P. polytes and P. memnon. / Iijima, Takuro; Kajitani, Rei; Komata, Shinya; Lin, Chung-Ping; Sota, Teiji; Itoh, Takehiko; Fujiwara, Haruhiko.

In: Science Advances, Vol. 4, No. 4, eaao5416, 18.04.2018.

Research output: Contribution to journalArticle

Iijima, Takuro ; Kajitani, Rei ; Komata, Shinya ; Lin, Chung-Ping ; Sota, Teiji ; Itoh, Takehiko ; Fujiwara, Haruhiko. / Parallel evolution of Batesian mimicry supergene in two Papilio butterflies, P. polytes and P. memnon. In: Science Advances. 2018 ; Vol. 4, No. 4.
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