Palladium-catalyzed tandem C-H functionalization/cyclization strategy for the synthesis of 5-hydroxybenzofuran derivatives

Sachin S. Ichake, Ashok Konala, Veerababurao Kavala, Chun Wei Kuo, Ching Fa Yao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A palladium-catalyzed benzoquinone C-H functionalization/ cyclization strategy with terminal alkynes was employed for the synthesis of some biologically relevant 2, 3-disubstituted 5-hydroxybenzofuran derivatives. The benzoquinone acts as a reactant as well as an oxidant. During the process, an additional alkyne functionality can be introduced at the C3 position of the benzofuran. Base, ligand, and external oxidant are not required in this protocol.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalOrganic Letters
Volume19
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Alkynes
Cyclization
Palladium
quinones
alkynes
Oxidants
palladium
Derivatives
synthesis
Ligands
ligands
benzoquinone
benzofuran

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Palladium-catalyzed tandem C-H functionalization/cyclization strategy for the synthesis of 5-hydroxybenzofuran derivatives. / Ichake, Sachin S.; Konala, Ashok; Kavala, Veerababurao; Kuo, Chun Wei; Yao, Ching Fa.

In: Organic Letters, Vol. 19, No. 1, 01.01.2017, p. 54-57.

Research output: Contribution to journalArticle

Ichake, Sachin S. ; Konala, Ashok ; Kavala, Veerababurao ; Kuo, Chun Wei ; Yao, Ching Fa. / Palladium-catalyzed tandem C-H functionalization/cyclization strategy for the synthesis of 5-hydroxybenzofuran derivatives. In: Organic Letters. 2017 ; Vol. 19, No. 1. pp. 54-57.
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