Abstract
We have developed an efficient synthetic method for the production of substituted tetrahydropyrano[2, 3-c]pyrazoles using (E)-2-nitro-1,3-enynes, 1-aryl-3-substituted pyrazolones and methyl vinyl ketone. The sequential, one-pot reaction proceeded smoothly to give the desired products in high to excellent yields and stereoselectivities in the presence of a quinine-derived squaramide organocatalyst.
| Original language | English |
|---|---|
| Pages (from-to) | 3500-3504 |
| Number of pages | 5 |
| Journal | ChemistrySelect |
| Volume | 3 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2018 Mar 29 |
Keywords
- (E)-2-nitro-1,3-enynes
- Michael reaction
- organocatalysis
- pyrazolone
- stereoselectivity
ASJC Scopus subject areas
- General Chemistry
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Dive into the research topics of 'Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles'. Together they form a unique fingerprint.Datasets
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CCDC 1552399: Experimental Crystal Structure Determination
Wu, C. (Creator) & Chen, K. (Creator), Unknown Publisher, 2019
DOI: 10.5517/ccdc.csd.cc1p3ddl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1p3ddl&sid=DataCite
Dataset
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CCDC 1552396: Experimental Crystal Structure Determination
Wu, C. (Creator) & Chen, K. (Creator), Unknown Publisher, 2019
DOI: 10.5517/ccdc.csd.cc1p3d9h, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1p3d9h&sid=DataCite
Dataset