Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles

Chia Yu Wu, Kwunmin Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have developed an efficient synthetic method for the production of substituted tetrahydropyrano[2, 3-c]pyrazoles using (E)-2-nitro-1,3-enynes, 1-aryl-3-substituted pyrazolones and methyl vinyl ketone. The sequential, one-pot reaction proceeded smoothly to give the desired products in high to excellent yields and stereoselectivities in the presence of a quinine-derived squaramide organocatalyst.

Original languageEnglish
Pages (from-to)3500-3504
Number of pages5
JournalChemistrySelect
Volume3
Issue number12
DOIs
Publication statusPublished - 2018 Mar 29

Fingerprint

Pyrazolones
Pyrazoles
Stereoselectivity
Quinine
3-buten-2-one

Keywords

  • (E)-2-nitro-1,3-enynes
  • Michael reaction
  • organocatalysis
  • pyrazolone
  • stereoselectivity

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles. / Wu, Chia Yu; Chen, Kwunmin.

In: ChemistrySelect, Vol. 3, No. 12, 29.03.2018, p. 3500-3504.

Research output: Contribution to journalArticle

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