Abstract
A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.
| Original language | English |
|---|---|
| Pages (from-to) | 2888-2891 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 76 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2011 Apr 15 |
ASJC Scopus subject areas
- Organic Chemistry
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Syu, S. E., Lee, Y. T., Jang, Y. J., & Lin, W-W. (2011). Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction. Journal of Organic Chemistry, 76(8), 2888-2891. https://doi.org/10.1021/jo102143r