Abstract
A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.
Original language | English |
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Pages (from-to) | 2888-2891 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 76 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2011 Apr 15 |
ASJC Scopus subject areas
- Organic Chemistry