Abstract
A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.
| Original language | English |
|---|---|
| Pages (from-to) | 2888-2891 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 76 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2011 Apr 15 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction. / Syu, Siang En; Lee, Yu Ting; Jang, Yeong Jiunn; Lin, Wen-Wei.
In: Journal of Organic Chemistry, Vol. 76, No. 8, 15.04.2011, p. 2888-2891.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction
AU - Syu, Siang En
AU - Lee, Yu Ting
AU - Jang, Yeong Jiunn
AU - Lin, Wen-Wei
PY - 2011/4/15
Y1 - 2011/4/15
N2 - A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.
AB - A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.
UR - http://www.scopus.com/inward/record.url?scp=79953870516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953870516&partnerID=8YFLogxK
U2 - 10.1021/jo102143r
DO - 10.1021/jo102143r
M3 - Article
C2 - 21401084
AN - SCOPUS:79953870516
VL - 76
SP - 2888
EP - 2891
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 8
ER -