Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction

Siang En Syu, Yu Ting Lee, Yeong Jiunn Jang, Wen-Wei Lin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.

Original languageEnglish
Pages (from-to)2888-2891
Number of pages4
JournalJournal of Organic Chemistry
Volume76
Issue number8
DOIs
Publication statusPublished - 2011 Apr 15

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Imides
Imines
Ketones
succinimide
phthalimide

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction. / Syu, Siang En; Lee, Yu Ting; Jang, Yeong Jiunn; Lin, Wen-Wei.

In: Journal of Organic Chemistry, Vol. 76, No. 8, 15.04.2011, p. 2888-2891.

Research output: Contribution to journalArticle

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