Organocatalytic tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide: One-pot syntheses of highly functional alkenes

De Wei Wang, Siang En Syu, Yi Ting Hung, Pei Yi Chen, Chia Jui Lee, Ko Wei Chen, Yu Jhang Chen, Wenwei Lin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An EtPPh2- or PPh3-catalyzed tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide is developed. Its further application in one-pot syntheses of highly functional alkenes starting from aldehydes, alkyl vinyl ketones, and amides is realized. A wide variety of highly functional α,β-unsaturated ketones can be furnished in 68-99% yields with high stereoselectivity (E/Z up to 98:2) within overall 3-29.5 h.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number2
DOIs
Publication statusPublished - 2011 Jan 21

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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