Organocatalytic synthesis of spirocarbocycles

You Song Cheng, Shaik Anwar, Kwunmin Chen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


The efficient construction of C-C bonds with multiple stereocenters has been of synthetic interest to the synthetic community. This review describes the organocatalytic cascade, domino or tandem synthesis of spirocarbocycles that evolved through the use of small organic catalysts. Spirocarbocycles are frequently observed in organic compounds in nature, and the formation of spirocarbocycles is vital in contemporary organic synthesis. These reactions proceed through the combination of enamine, iminium, dienamine, and trienamine modes of activation to construct multiple C-C bonds with newly generated stereogenic centers.

Original languageEnglish
Pages (from-to)364-373
Number of pages10
JournalMini-Reviews in Organic Chemistry
Issue number5
Publication statusPublished - 2018


  • C-C bonds
  • Cascade reaction
  • Enantioselectivity
  • Organocatalytic
  • Spirocarbocycles
  • Tandem strategies

ASJC Scopus subject areas

  • Organic Chemistry


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