Organocatalytic synthesis of spirocarbocycles

You Song Cheng; Shaik Anwar; Kwunmin Chen

doi:10.2174/1570193X15666171228145726

Organocatalytic synthesis of spirocarbocycles

You Song Cheng, Shaik Anwar, Kwunmin Chen^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

The efficient construction of C-C bonds with multiple stereocenters has been of synthetic interest to the synthetic community. This review describes the organocatalytic cascade, domino or tandem synthesis of spirocarbocycles that evolved through the use of small organic catalysts. Spirocarbocycles are frequently observed in organic compounds in nature, and the formation of spirocarbocycles is vital in contemporary organic synthesis. These reactions proceed through the combination of enamine, iminium, dienamine, and trienamine modes of activation to construct multiple C-C bonds with newly generated stereogenic centers.

Original language	English
Pages (from-to)	364-373
Number of pages	10
Journal	Mini-Reviews in Organic Chemistry
Volume	15
Issue number	5
DOIs	https://doi.org/10.2174/1570193X15666171228145726
Publication status	Published - 2018

Keywords

C-C bonds
Cascade reaction
Enantioselectivity
Organocatalytic
Spirocarbocycles
Tandem strategies

ASJC Scopus subject areas

Organic Chemistry

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10.2174/1570193X15666171228145726

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title = "Organocatalytic synthesis of spirocarbocycles",

abstract = "The efficient construction of C-C bonds with multiple stereocenters has been of synthetic interest to the synthetic community. This review describes the organocatalytic cascade, domino or tandem synthesis of spirocarbocycles that evolved through the use of small organic catalysts. Spirocarbocycles are frequently observed in organic compounds in nature, and the formation of spirocarbocycles is vital in contemporary organic synthesis. These reactions proceed through the combination of enamine, iminium, dienamine, and trienamine modes of activation to construct multiple C-C bonds with newly generated stereogenic centers.",

keywords = "C-C bonds, Cascade reaction, Enantioselectivity, Organocatalytic, Spirocarbocycles, Tandem strategies",

author = "Cheng, {You Song} and Shaik Anwar and Kwunmin Chen",

note = "Publisher Copyright: {\textcopyright} 2018 Bentham Science Publishers.",

year = "2018",

doi = "10.2174/1570193X15666171228145726",

language = "English",

volume = "15",

pages = "364--373",

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TY - JOUR

T1 - Organocatalytic synthesis of spirocarbocycles

AU - Cheng, You Song

AU - Anwar, Shaik

AU - Chen, Kwunmin

PY - 2018

Y1 - 2018

N2 - The efficient construction of C-C bonds with multiple stereocenters has been of synthetic interest to the synthetic community. This review describes the organocatalytic cascade, domino or tandem synthesis of spirocarbocycles that evolved through the use of small organic catalysts. Spirocarbocycles are frequently observed in organic compounds in nature, and the formation of spirocarbocycles is vital in contemporary organic synthesis. These reactions proceed through the combination of enamine, iminium, dienamine, and trienamine modes of activation to construct multiple C-C bonds with newly generated stereogenic centers.

AB - The efficient construction of C-C bonds with multiple stereocenters has been of synthetic interest to the synthetic community. This review describes the organocatalytic cascade, domino or tandem synthesis of spirocarbocycles that evolved through the use of small organic catalysts. Spirocarbocycles are frequently observed in organic compounds in nature, and the formation of spirocarbocycles is vital in contemporary organic synthesis. These reactions proceed through the combination of enamine, iminium, dienamine, and trienamine modes of activation to construct multiple C-C bonds with newly generated stereogenic centers.

KW - C-C bonds

KW - Cascade reaction

KW - Enantioselectivity

KW - Organocatalytic

KW - Spirocarbocycles

KW - Tandem strategies

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DO - 10.2174/1570193X15666171228145726

M3 - Review article

AN - SCOPUS:85051669075

SN - 1570-193X

VL - 15

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EP - 373

JO - Mini-Reviews in Organic Chemistry

JF - Mini-Reviews in Organic Chemistry

IS - 5

ER -

Organocatalytic synthesis of spirocarbocycles

Abstract

Keywords

ASJC Scopus subject areas

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