Chemical equations presented. An efficient and unprecedented organocatalytic reaction of γ-nitroketones with α,β-unsaturated aldehydes to give polyfunctionalized [4.4.0] bicyclic skeletons was developed. The diphenylprolinol silyl ether mediated nitro-Michael/Aldol reaction afforded the hexa-substituted decalin carboaldehydes with excellent diastereo- and enantioselectivity (up to >99:1 dr and >99% ee) via a formal [4 + 2] carbocyclization process.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
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Chen, K. (Contributor), Anwar, S. (Contributor) & Chang, H. (Contributor), Unknown Publisher, 2011 May 6
Chen, K. (Contributor), Chang, H. (Contributor) & Anwar, S. (Contributor), Unknown Publisher, 2011 May 6