Abstract
A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
| Original language | English |
|---|---|
| Pages (from-to) | 1985-1992 |
| Number of pages | 8 |
| Journal | Journal of Organic Chemistry |
| Volume | 80 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Feb 6 |
ASJC Scopus subject areas
- Organic Chemistry
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Dive into the research topics of 'Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes'. Together they form a unique fingerprint.Datasets
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CCDC 1025579: Experimental Crystal Structure Determination
Chen, Y. (Creator), Das, U. (Creator), Liu, M. (Creator) & Lin, W. (Creator), Unknown Publisher, 2015
DOI: 10.5517/cc13f66y, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc13f66y&sid=DataCite
Dataset
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CCDC 1025110: Experimental Crystal Structure Determination
Chen, Y. (Creator), Das, U. (Creator), Liu, M. (Creator) & Lin, W. (Creator), Unknown Publisher, 2015
DOI: 10.5517/cc13dq29, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc13dq29&sid=DataCite
Dataset
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CCDC 1033384: Experimental Crystal Structure Determination
Chen, Y. (Creator), Das, U. (Creator), Liu, M. (Creator) & Lin, W. (Creator), Unknown Publisher, 2015
DOI: 10.5517/cc13p9z2, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc13p9z2&sid=DataCite
Dataset