Abstract
A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
| Original language | English |
|---|---|
| Pages (from-to) | 1985-1992 |
| Number of pages | 8 |
| Journal | Journal of Organic Chemistry |
| Volume | 80 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Feb 6 |
ASJC Scopus subject areas
- Organic Chemistry
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Chen, Y. R., Das, U., Liu, M. H., & Lin, W. (2015). Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes. Journal of Organic Chemistry, 80(3), 1985-1992. https://doi.org/10.1021/jo5027047