Abstract
A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
Original language | English |
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Pages (from-to) | 1985-1992 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2015 Feb 6 |
ASJC Scopus subject areas
- Organic Chemistry