Abstract
A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
Original language | English |
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Pages (from-to) | 1985-1992 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2015 Feb 6 |
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ASJC Scopus subject areas
- Organic Chemistry
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Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes. / Chen, Yi Ru; Das, Utpal; Liu, Meng Hsien; Lin, Wen-Wei.
In: Journal of Organic Chemistry, Vol. 80, No. 3, 06.02.2015, p. 1985-1992.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes
AU - Chen, Yi Ru
AU - Das, Utpal
AU - Liu, Meng Hsien
AU - Lin, Wen-Wei
PY - 2015/2/6
Y1 - 2015/2/6
N2 - A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
AB - A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
UR - http://www.scopus.com/inward/record.url?scp=84922712502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922712502&partnerID=8YFLogxK
U2 - 10.1021/jo5027047
DO - 10.1021/jo5027047
M3 - Article
C2 - 25562697
AN - SCOPUS:84922712502
VL - 80
SP - 1985
EP - 1992
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 3
ER -