Abstract
A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.
| Original language | English |
|---|---|
| Pages (from-to) | 1985-1992 |
| Number of pages | 8 |
| Journal | Journal of Organic Chemistry |
| Volume | 80 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Feb 6 |
ASJC Scopus subject areas
- Organic Chemistry
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Dive into the research topics of 'Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes'. Together they form a unique fingerprint.Datasets
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CCDC 1025110: Experimental Crystal Structure Determination
Lin, W. (Contributor), Liu, M. (Contributor), Das, U. (Contributor) & Chen, Y. (Contributor), Unknown Publisher, 2015 Feb 6
DOI: 10.5517/cc13dq29, https://doi.org/10.5517%2Fcc13dq29
Dataset
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CCDC 1025579: Experimental Crystal Structure Determination
Liu, M. (Contributor), Lin, W. (Contributor), Das, U. (Contributor) & Chen, Y. (Contributor), Unknown Publisher, 2015 Feb 6
DOI: 10.5517/cc13f66y, https://doi.org/10.5517%2Fcc13f66y
Dataset
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CCDC 1033384: Experimental Crystal Structure Determination
Chen, Y. (Contributor), Das, U. (Contributor), Liu, M. (Contributor) & Lin, W. (Contributor), Unknown Publisher, 2015 Feb 6
DOI: 10.5517/cc13p9z2, https://doi.org/10.5517%2Fcc13p9z2
Dataset