Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes

Yi Ru Chen, Utpal Das, Meng Hsien Liu, Wenwei Lin

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A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.

Original languageEnglish
Pages (from-to)1985-1992
Number of pages8
JournalJournal of Organic Chemistry
Issue number3
Publication statusPublished - 2015 Feb 6


ASJC Scopus subject areas

  • Organic Chemistry

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