Abstract
Adding value: The direct vinylogous Michael addition of γ-substituted butenolides with a series of 3-aroyl acrylates and 1,2-diaroylethylenes has been demonstrated. This organocatalytic method delivers highly enantio- and diastereomerically pure γ,γ-disubstituted butenolides with adjacent quaternary and tertiary stereocenters (see scheme).
| Original language | English |
|---|---|
| Pages (from-to) | 7713-7717 |
| Number of pages | 5 |
| Journal | Chemistry - A European Journal |
| Volume | 19 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - 2013 Jun 10 |
Keywords
- Michael addition
- cinchona alkaloids
- organocatalysis
- quaternary stereogenic center
- γ-butenolides
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Cite this
Das, U., Chen, Y. R., Tsai, Y. L., & Lin, W-W. (2013). Organocatalytic enantioselective direct vinylogous michael addition of γ-substituted butenolides to 3-aroyl acrylates and 1,2-diaroylethylenes. Chemistry - A European Journal, 19(24), 7713-7717. https://doi.org/10.1002/chem.201301332