Abstract
Adding value: The direct vinylogous Michael addition of γ-substituted butenolides with a series of 3-aroyl acrylates and 1,2-diaroylethylenes has been demonstrated. This organocatalytic method delivers highly enantio- and diastereomerically pure γ,γ-disubstituted butenolides with adjacent quaternary and tertiary stereocenters (see scheme).
Original language | English |
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Pages (from-to) | 7713-7717 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 19 |
Issue number | 24 |
DOIs | |
Publication status | Published - 2013 Jun 10 |
Keywords
- Michael addition
- cinchona alkaloids
- organocatalysis
- quaternary stereogenic center
- γ-butenolides
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry