Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS

An Shu Liau; Ju Tsung Liu; Li Chan Lin; Yu Chih Chiu; You Ren Shu; Chung Chen Tsai; Cheng Huang Lin

doi:10.1016/S0379-0738(03)00096-3

Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS

An Shu Liau, Ju Tsung Liu, Li Chan Lin, Yu Chih Chiu, You Ren Shu, Chung Chen Tsai, Cheng Huang Lin^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

The chiral separation of (±)-methamphetamine, (±)-methcathinone, (±)-ephedrine and (±)-pseudoephedrine by means of β-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of β-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.

Original language	English
Pages (from-to)	17-24
Number of pages	8
Journal	Forensic Science International
Volume	134
Issue number	1
DOIs	https://doi.org/10.1016/S0379-0738(03)00096-3
Publication status	Published - 2003 Jun 24

Keywords

(±)- Ephedrine
(±)-Methamphetamine
(±)-Methcathinone
(±)-Pseudoephedrine
Capillary electrophoresis
Chiral separation

ASJC Scopus subject areas

Pathology and Forensic Medicine

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Liau, A. S., Liu, J. T., Lin, L. C., Chiu, Y. C., Shu, Y. R., Tsai, C. C., & Lin, C. H. (2003). Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS. Forensic Science International, 134(1), 17-24. https://doi.org/10.1016/S0379-0738(03)00096-3

Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis : A complementary method to GC-MS. / Liau, An Shu; Liu, Ju Tsung; Lin, Li Chan et al.

In: Forensic Science International, Vol. 134, No. 1, 24.06.2003, p. 17-24.

Research output: Contribution to journal › Article › peer-review

Liau, AS, Liu, JT, Lin, LC, Chiu, YC, Shu, YR, Tsai, CC & Lin, CH 2003, 'Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS', Forensic Science International, vol. 134, no. 1, pp. 17-24. https://doi.org/10.1016/S0379-0738(03)00096-3

Liau AS, Liu JT, Lin LC, Chiu YC, Shu YR, Tsai CC et al. Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS. Forensic Science International. 2003 Jun 24;134(1):17-24. doi: 10.1016/S0379-0738(03)00096-3

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title = "Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS",

abstract = "The chiral separation of (±)-methamphetamine, (±)-methcathinone, (±)-ephedrine and (±)-pseudoephedrine by means of β-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of β-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.",

keywords = "(±)- Ephedrine, (±)-Methamphetamine, (±)-Methcathinone, (±)-Pseudoephedrine, Capillary electrophoresis, Chiral separation",

author = "Liau, {An Shu} and Liu, {Ju Tsung} and Lin, {Li Chan} and Chiu, {Yu Chih} and Shu, {You Ren} and Tsai, {Chung Chen} and Lin, {Cheng Huang}",

note = "Funding Information: This work was supported by a grant from the National Science Council of Taiwan under Contract no. 90-2113-M-003-020. Permission was obtained from Pharmaceutical Affairs, Department of Health, Taiwan (License number: ARR089000035). The authors wish to thank the Forensic Science Center (Taiwan Command of the Army Force of Military Police) for generously donating the urine samples and amphetamine standards.",

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doi = "10.1016/S0379-0738(03)00096-3",

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T2 - A complementary method to GC-MS

AU - Liau, An Shu

AU - Liu, Ju Tsung

AU - Lin, Li Chan

AU - Chiu, Yu Chih

AU - Shu, You Ren

AU - Tsai, Chung Chen

AU - Lin, Cheng Huang

N1 - Funding Information: This work was supported by a grant from the National Science Council of Taiwan under Contract no. 90-2113-M-003-020. Permission was obtained from Pharmaceutical Affairs, Department of Health, Taiwan (License number: ARR089000035). The authors wish to thank the Forensic Science Center (Taiwan Command of the Army Force of Military Police) for generously donating the urine samples and amphetamine standards.

PY - 2003/6/24

Y1 - 2003/6/24

N2 - The chiral separation of (±)-methamphetamine, (±)-methcathinone, (±)-ephedrine and (±)-pseudoephedrine by means of β-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of β-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.

AB - The chiral separation of (±)-methamphetamine, (±)-methcathinone, (±)-ephedrine and (±)-pseudoephedrine by means of β-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of β-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.

KW - (±)- Ephedrine

KW - (±)-Methamphetamine

KW - (±)-Methcathinone

KW - (±)-Pseudoephedrine

KW - Capillary electrophoresis

KW - Chiral separation

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Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS

Abstract

Keywords

ASJC Scopus subject areas

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