Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis: A complementary method to GC-MS

An Shu Liau, Ju Tsung Liu, Li Chan Lin, Yu Chih Chiu, You Ren Shu, Chung Chen Tsai, Cheng Huang Lin

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46 Citations (Scopus)

Abstract

The chiral separation of (±)-methamphetamine, (±)-methcathinone, (±)-ephedrine and (±)-pseudoephedrine by means of β-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of β-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalForensic Science International
Volume134
Issue number1
DOIs
Publication statusPublished - 2003 Jun 24

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Keywords

  • (±)- Ephedrine
  • (±)-Methamphetamine
  • (±)-Methcathinone
  • (±)-Pseudoephedrine
  • Capillary electrophoresis
  • Chiral separation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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