Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis

A complementary method to GC-MS

An Shu Liau, Ju Tsung Liu, Li Chan Lin, Yu Chih Chiu, You Ren Shu, Chung Chen Tsai, Cheng-Huang Lin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The chiral separation of (±)-methamphetamine, (±)-methcathinone, (±)-ephedrine and (±)-pseudoephedrine by means of β-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of β-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalForensic Science International
Volume134
Issue number1
DOIs
Publication statusPublished - 2003 Jun 24

Fingerprint

Methamphetamine
Capillary Electrophoresis
Tablets
Urine
Pseudoephedrine
Ephedrine
Cyclodextrins
Temperature
monomethylpropion

Keywords

  • (±)- Ephedrine
  • (±)-Methamphetamine
  • (±)-Methcathinone
  • (±)-Pseudoephedrine
  • Capillary electrophoresis
  • Chiral separation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by β-cyclodextrine modified capillary electrophoresis : A complementary method to GC-MS. / Liau, An Shu; Liu, Ju Tsung; Lin, Li Chan; Chiu, Yu Chih; Shu, You Ren; Tsai, Chung Chen; Lin, Cheng-Huang.

In: Forensic Science International, Vol. 134, No. 1, 24.06.2003, p. 17-24.

Research output: Contribution to journalArticle

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AU - Tsai, Chung Chen

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