Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode

Feng Yu Chang, Meng Tsan Tsai, Zu Yi Wang, Chun Kai Chi, Cheng Kuang Lee, Chih Hsun Yang, Ming Che Chan, Ya-Ju Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Blood coagulation is the clotting and subsequent dissolution of the clot following repair to the damaged tissue. However, inducing blood coagulation is difficult for some patients with homeostasis dysfunction or during surgery. In this study, we proposed a method to develop an integrated system that combines optical coherence tomography (OCT) and laser microsurgery for blood coagulation. Also, an algorithm for positioning of the treatment location from OCT images was developed. With OCT scanning, 2D/3D OCT images and angiography of tissue can be obtained simultaneously, enabling to noninvasively reconstruct the morphological and microvascular structures for real-time monitoring of changes in biological tissues during laser microsurgery. Instead of high-cost pulsed lasers, continuous-wave laser diodes (CW-LDs) with the central wavelengths of 450 nm and 532 nm are used for blood coagulation, corresponding to higher absorption coefficients of oxyhemoglobin and deoxyhemoglobin. Experimental results showed that the location of laser exposure can be accurately controlled with the proposed approach of imaging-based feedback positioning. Moreover, blood coagulation can be efficiently induced by CW-LDs and the coagulation process can be monitored in real-time with OCT. This technology enables to potentially provide accurate positioning for laser microsurgery and control the laser exposure to avoid extra damage by real-time OCT imaging.

Original languageEnglish
Article number16739
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 2015 Nov 16

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Microsurgery
Optical Coherence Tomography
Blood Coagulation
Lasers
Laser Coagulation
Oxyhemoglobins
Angiography
Homeostasis
Technology
Costs and Cost Analysis

ASJC Scopus subject areas

  • General

Cite this

Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode. / Chang, Feng Yu; Tsai, Meng Tsan; Wang, Zu Yi; Chi, Chun Kai; Lee, Cheng Kuang; Yang, Chih Hsun; Chan, Ming Che; Lee, Ya-Ju.

In: Scientific Reports, Vol. 5, 16739, 16.11.2015.

Research output: Contribution to journalArticle

Chang, Feng Yu ; Tsai, Meng Tsan ; Wang, Zu Yi ; Chi, Chun Kai ; Lee, Cheng Kuang ; Yang, Chih Hsun ; Chan, Ming Che ; Lee, Ya-Ju. / Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode. In: Scientific Reports. 2015 ; Vol. 5.
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