One-pot synthesis of the hydroximoyl chlorides and [3.3.0] bicyclic compounds from the reactions of β-nitrostyrenes with stabilized nucleophiles

Kuo Hsi Kao, Cherng Shi Yang, Ju Tsung Liu, Wen Wei Lin, Hui Yu Fang, Ching Fa Yao, Kwunmin Chen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

β-Nitrostyrenes 1 react with various stabilized nucleophiles to generate hydroximoyl chlorides and nitroalkanes after workup with ice cold concentrated hydrochloric acid. One-pot synthesis of bicyclic products from the Michael addition of different nucleophiles with β-nitrostyrenes 1 is reported.

Original languageEnglish
Pages (from-to)13997-14014
Number of pages18
JournalTetrahedron
Volume54
Issue number46
DOIs
Publication statusPublished - 1998 Nov 12

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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