On-line identification of lysergic acid diethylamide (LSD) in tablets using a combination of a sweeping technique and micellar electrokinetic chromatography/77 K fluorescence spectroscopy

Ching Fang, Ju Tsung Liu, Cheng Huang Lin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This work describes a novel method for the accurate determination of lysergic acid diethylamide (LSD) in tablets. A technique involving sweeping-micellar electrokinetic chromatography (MEKC) was used for the initial on-line concentration and separation, after which a cryogenic molecular fluorescence experiment was performed at 77 K. Using this approach, not only the separation of LSD from the tablet extract was achieved, but on-line spectra were readily distinguishable and could be unambiguously assigned. The results are in agreement with analyses by gas chromatography-mass spectrometry (GC-MS). Thus, this method, which was found to be accurate, sensitive and rapid, has the potential for use as a reliable complementary method to GC-MS in such analyses.

Original languageEnglish
Pages (from-to)1025-1030
Number of pages6
JournalElectrophoresis
Volume24
Issue number6
DOIs
Publication statusPublished - 2003 Mar 1

Fingerprint

Lysergic Acid Diethylamide
Fluorescence Spectrometry
Fluorescence spectroscopy
Chromatography
Gas chromatography
Tablets
Mass spectrometry
Gas Chromatography-Mass Spectrometry
Cryogenics
Fluorescence
Experiments

Keywords

  • Gas chromatography-mass spectrometry
  • Low-temperature fluorescence spectroscopy
  • Lysergic acid diethylamide (LSD)
  • Micellar electrokinetic chromatography
  • Sweeping

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Cite this

@article{5ec44197fd20415d9e8ab11e69409461,
title = "On-line identification of lysergic acid diethylamide (LSD) in tablets using a combination of a sweeping technique and micellar electrokinetic chromatography/77 K fluorescence spectroscopy",
abstract = "This work describes a novel method for the accurate determination of lysergic acid diethylamide (LSD) in tablets. A technique involving sweeping-micellar electrokinetic chromatography (MEKC) was used for the initial on-line concentration and separation, after which a cryogenic molecular fluorescence experiment was performed at 77 K. Using this approach, not only the separation of LSD from the tablet extract was achieved, but on-line spectra were readily distinguishable and could be unambiguously assigned. The results are in agreement with analyses by gas chromatography-mass spectrometry (GC-MS). Thus, this method, which was found to be accurate, sensitive and rapid, has the potential for use as a reliable complementary method to GC-MS in such analyses.",
keywords = "Gas chromatography-mass spectrometry, Low-temperature fluorescence spectroscopy, Lysergic acid diethylamide (LSD), Micellar electrokinetic chromatography, Sweeping",
author = "Ching Fang and Liu, {Ju Tsung} and Lin, {Cheng Huang}",
year = "2003",
month = "3",
day = "1",
doi = "10.1002/elps.200390118",
language = "English",
volume = "24",
pages = "1025--1030",
journal = "Electrophoresis",
issn = "0173-0835",
publisher = "Wiley-VCH Verlag",
number = "6",

}

TY - JOUR

T1 - On-line identification of lysergic acid diethylamide (LSD) in tablets using a combination of a sweeping technique and micellar electrokinetic chromatography/77 K fluorescence spectroscopy

AU - Fang, Ching

AU - Liu, Ju Tsung

AU - Lin, Cheng Huang

PY - 2003/3/1

Y1 - 2003/3/1

N2 - This work describes a novel method for the accurate determination of lysergic acid diethylamide (LSD) in tablets. A technique involving sweeping-micellar electrokinetic chromatography (MEKC) was used for the initial on-line concentration and separation, after which a cryogenic molecular fluorescence experiment was performed at 77 K. Using this approach, not only the separation of LSD from the tablet extract was achieved, but on-line spectra were readily distinguishable and could be unambiguously assigned. The results are in agreement with analyses by gas chromatography-mass spectrometry (GC-MS). Thus, this method, which was found to be accurate, sensitive and rapid, has the potential for use as a reliable complementary method to GC-MS in such analyses.

AB - This work describes a novel method for the accurate determination of lysergic acid diethylamide (LSD) in tablets. A technique involving sweeping-micellar electrokinetic chromatography (MEKC) was used for the initial on-line concentration and separation, after which a cryogenic molecular fluorescence experiment was performed at 77 K. Using this approach, not only the separation of LSD from the tablet extract was achieved, but on-line spectra were readily distinguishable and could be unambiguously assigned. The results are in agreement with analyses by gas chromatography-mass spectrometry (GC-MS). Thus, this method, which was found to be accurate, sensitive and rapid, has the potential for use as a reliable complementary method to GC-MS in such analyses.

KW - Gas chromatography-mass spectrometry

KW - Low-temperature fluorescence spectroscopy

KW - Lysergic acid diethylamide (LSD)

KW - Micellar electrokinetic chromatography

KW - Sweeping

UR - http://www.scopus.com/inward/record.url?scp=0347765632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347765632&partnerID=8YFLogxK

U2 - 10.1002/elps.200390118

DO - 10.1002/elps.200390118

M3 - Article

C2 - 12658691

AN - SCOPUS:0347765632

VL - 24

SP - 1025

EP - 1030

JO - Electrophoresis

JF - Electrophoresis

SN - 0173-0835

IS - 6

ER -