On-line identification of lysergic acid diethylamide (LSD) in tablets using a combination of a sweeping technique and micellar electrokinetic chromatography/77 K fluorescence spectroscopy

Ching Fang, Ju Tsung Liu, Cheng Huang Lin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This work describes a novel method for the accurate determination of lysergic acid diethylamide (LSD) in tablets. A technique involving sweeping-micellar electrokinetic chromatography (MEKC) was used for the initial on-line concentration and separation, after which a cryogenic molecular fluorescence experiment was performed at 77 K. Using this approach, not only the separation of LSD from the tablet extract was achieved, but on-line spectra were readily distinguishable and could be unambiguously assigned. The results are in agreement with analyses by gas chromatography-mass spectrometry (GC-MS). Thus, this method, which was found to be accurate, sensitive and rapid, has the potential for use as a reliable complementary method to GC-MS in such analyses.

Original languageEnglish
Pages (from-to)1025-1030
Number of pages6
JournalElectrophoresis
Volume24
Issue number6
DOIs
Publication statusPublished - 2003 Mar 1

Keywords

  • Gas chromatography-mass spectrometry
  • Low-temperature fluorescence spectroscopy
  • Lysergic acid diethylamide (LSD)
  • Micellar electrokinetic chromatography
  • Sweeping

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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