Nucleosides XIII. Facile synthesis of 4-amino-1-(2-deoxy-β-D- ribofuranosyl)quinazolin-2-one as a 2′-deoxycytidine analog for oligonucleotide synthesis

Tun Cheng Chien; Chien Shu Chen; Ji Wang Chern

doi:10.1002/jccs.200500178

Nucleosides XIII. Facile synthesis of 4-amino-1-(2-deoxy-β-D- ribofuranosyl)quinazolin-2-one as a 2′-deoxycytidine analog for oligonucleotide synthesis

Tun Cheng Chien, Chien Shu Chen, Ji Wang Chern^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.

Original language	English
Pages (from-to)	1237-1244
Number of pages	8
Journal	Journal of the Chinese Chemical Society
Volume	52
Issue number	6
DOIs	https://doi.org/10.1002/jccs.200500178
Publication status	Published - 2005
Externally published	Yes

Keywords

2′-Deoxycytidine
Barton deoxygenation
Cytidine
Markiewicz silylation
Quinazolinone

ASJC Scopus subject areas

Chemistry(all)

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10.1002/jccs.200500178

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title = "Nucleosides XIII. Facile synthesis of 4-amino-1-(2-deoxy-β-D- ribofuranosyl)quinazolin-2-one as a 2′-deoxycytidine analog for oligonucleotide synthesis",

abstract = "4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.",

keywords = "2′-Deoxycytidine, Barton deoxygenation, Cytidine, Markiewicz silylation, Quinazolinone",

author = "Chien, {Tun Cheng} and Chen, {Chien Shu} and Chern, {Ji Wang}",

year = "2005",

doi = "10.1002/jccs.200500178",

language = "English",

volume = "52",

pages = "1237--1244",

journal = "Journal of the Chinese Chemical Society",

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AU - Chien, Tun Cheng

AU - Chen, Chien Shu

AU - Chern, Ji Wang

PY - 2005

Y1 - 2005

N2 - 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.

AB - 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.

KW - 2′-Deoxycytidine

KW - Barton deoxygenation

KW - Cytidine

KW - Markiewicz silylation

KW - Quinazolinone

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Nucleosides XIII. Facile synthesis of 4-amino-1-(2-deoxy-β-D- ribofuranosyl)quinazolin-2-one as a 2′-deoxycytidine analog for oligonucleotide synthesis

Abstract

Keywords

ASJC Scopus subject areas

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