Nucleosides XIII. Facile synthesis of 4-amino-1-(2-deoxy-β-D- ribofuranosyl)quinazolin-2-one as a 2′-deoxycytidine analog for oligonucleotide synthesis

Tun Cheng Chien, Chien Shu Chen, Ji Wang Chern

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.

Original languageEnglish
Pages (from-to)1237-1244
Number of pages8
JournalJournal of the Chinese Chemical Society
Volume52
Issue number6
DOIs
Publication statusPublished - 2005 Jan 1

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Deoxycytidine
Nucleosides
Oligonucleotides

Keywords

  • 2′-Deoxycytidine
  • Barton deoxygenation
  • Cytidine
  • Markiewicz silylation
  • Quinazolinone

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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title = "Nucleosides XIII. Facile synthesis of 4-amino-1-(2-deoxy-β-D- ribofuranosyl)quinazolin-2-one as a 2′-deoxycytidine analog for oligonucleotide synthesis",
abstract = "4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.",
keywords = "2′-Deoxycytidine, Barton deoxygenation, Cytidine, Markiewicz silylation, Quinazolinone",
author = "Chien, {Tun Cheng} and Chen, {Chien Shu} and Chern, {Ji Wang}",
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doi = "10.1002/jccs.200500178",
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T1 - Nucleosides XIII. Facile synthesis of 4-amino-1-(2-deoxy-β-D- ribofuranosyl)quinazolin-2-one as a 2′-deoxycytidine analog for oligonucleotide synthesis

AU - Chien, Tun Cheng

AU - Chen, Chien Shu

AU - Chern, Ji Wang

PY - 2005/1/1

Y1 - 2005/1/1

N2 - 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.

AB - 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazo1in-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.

KW - 2′-Deoxycytidine

KW - Barton deoxygenation

KW - Cytidine

KW - Markiewicz silylation

KW - Quinazolinone

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