Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease

Chiung Mei Chen, I. Cheng Chen, Kuo Hsuan Chang, Yi Chun Chen, Rong Kuo Lyu, Yen Tzu Liu, Fen Ju Hu, Chih Ying Chao, Guey Jen Lee-Chen, Yih Ru Wu

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Both of environmental and genetic factors confer vulnerability to Parkinson's disease (PD). NR4A2 (Nurr1), a member of the steroid/thyroid hormone nuclear receptor superfamily, is essential for the neurogenesis and differentiation of dopaminergic neurons in the midbrain. Brain derived neurotrophic factor (BDNF) deficiency may play a role in the pathogenesis of PD, as the surviving dopaminergic nigrostriatal neurons have reduced levels of BDNF. This study examines whether BDNF V66M (c.196 G → A) or NR4A2 IVS6 +18insG polymorphism is associated with the risk of Taiwanese PD and the age of onset using a case-control study. The genotype or allele frequency distribution of both BDNF V66M and NR4A2 IVS6 +18insG polymorphisms was not significantly different between the cases and the controls. Neither BDNF nor NR4A2 polymorphism influences PD onset age. Notably, after stratification by sex, female individuals carrying the NR4A2 2G/2G genotype demonstrated a trend toward significant decrease in risk of developing PD (OR = 0.49, 95% CI = 0.25-0.96, P = 0.039). These results suggest that the NR4A2 IVS6 +18insG polymorphism may play a minor role in PD susceptibility among Taiwanese women.

Original languageEnglish
Pages (from-to)458-462
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume144
Issue number4
DOIs
Publication statusPublished - 2007 Jun 5

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Nuclear Receptor Subfamily 4, Group A, Member 2
Brain-Derived Neurotrophic Factor
Parkinson Disease
Dopaminergic Neurons
Age of Onset
Genotype
Thyroid Hormone Receptors
Disease Susceptibility
Neurogenesis
Cytoplasmic and Nuclear Receptors
Mesencephalon
Gene Frequency
Case-Control Studies
Steroids

Keywords

  • Age at onset
  • BDNF V66M
  • Disease association
  • NR4A2 IVS6 +18insG
  • Parkinson's disease

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease. / Chen, Chiung Mei; Chen, I. Cheng; Chang, Kuo Hsuan; Chen, Yi Chun; Lyu, Rong Kuo; Liu, Yen Tzu; Hu, Fen Ju; Chao, Chih Ying; Lee-Chen, Guey Jen; Wu, Yih Ru.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 144, No. 4, 05.06.2007, p. 458-462.

Research output: Contribution to journalArticle

Chen, Chiung Mei ; Chen, I. Cheng ; Chang, Kuo Hsuan ; Chen, Yi Chun ; Lyu, Rong Kuo ; Liu, Yen Tzu ; Hu, Fen Ju ; Chao, Chih Ying ; Lee-Chen, Guey Jen ; Wu, Yih Ru. / Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2007 ; Vol. 144, No. 4. pp. 458-462.
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