Novel water-soluble hexa(sulfobutyl)fullerene attenuates apoptosis formation after ischemic renal failure

Chiang Ting Chien, Chau Fong Chen, Long Y. Chiang, Ming Kuen Lai

Research output: Contribution to journalConference article

6 Citations (Scopus)

Abstract

The mechanism for apoptosis induction during the implantation of renal transplants or ischemia/reperfusion (I/R) injury might be related to the release of free radicals. Hexa(sulfobutyl)fullerene, a strong free radical scavenger, is an isomeric mixture of polyfunctional C60 derivative carrying six sulfobutyl groups. To elucidate the role of hexa(sulfobutyl)fullerene in the I/R induced renal damage of the rat kidneys, we used TUNEL, DNA laddering, quantitative PCR and western blot to evaluate the expression of apoptosis. We found that less apoptotic expression and up-regulation in bcl-xL, an anti-death gene, was found in the damaged kidneys with hexa(sulfobutyl)fullerene (100 μ g) pretreatment. It is suggested that the mechanism for hexa(sulfobutyl)fullerene attenuating I/R induced apoptosis in the rat kidney may be ascribed to the overexpression of bcl-xL.

Original languageEnglish
Pages (from-to)529-540
Number of pages12
JournalFullerene Science and Technology
Volume7
Issue number4
DOIs
Publication statusPublished - 1999 Jan 1

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ASJC Scopus subject areas

  • Chemical Engineering(all)

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