Non-invasive and high-sensitivity scanning detection of magnetic nanoparticles in animals using high-Tc scanning superconducting- quantum-interference-device biosusceptometry

Jen-Je Chieh, C. Y. Hong

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Although magnetic nanoparticles (MNPs) have been widely applied to animals in biomedicine, MNPs within animals should be examined in real time, in vivo, and without bio-damaged possibility to evaluate whether the bio-function of MNPs is valid or to further controls the biomedicinal process because of accompanying complex problems such as MNPs distribution and MNPs biodegradation. The non-invasive and high-sensitivity scanning detection of MNPs in animals using ac susceptometry based on a high-Tc superconducting quantum interference device (SQUID) is presented. The non-invasive results and biopsy results show good agreement, and two gold-standard biomedicine methods, Prussian blue stain and inductively coupled plasma, prove the magnetic results. This confirms that the future clinical diagnosis of bio-functional MNPs could be operated by using scanning SQUID biosusceptometry as conveniently as an ultrasonic probe.

    Original languageEnglish
    Article number084301
    JournalReview of Scientific Instruments
    Volume82
    Issue number8
    DOIs
    Publication statusPublished - 2011 Aug 1

    Fingerprint

    SQUIDs
    animals
    Animals
    Nanoparticles
    Scanning
    interference
    nanoparticles
    scanning
    sensitivity
    biodegradation
    Biopsy
    Inductively coupled plasma
    Biodegradation
    ultrasonics
    Gold
    Ultrasonics
    gold
    probes

    ASJC Scopus subject areas

    • Instrumentation

    Cite this

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    abstract = "Although magnetic nanoparticles (MNPs) have been widely applied to animals in biomedicine, MNPs within animals should be examined in real time, in vivo, and without bio-damaged possibility to evaluate whether the bio-function of MNPs is valid or to further controls the biomedicinal process because of accompanying complex problems such as MNPs distribution and MNPs biodegradation. The non-invasive and high-sensitivity scanning detection of MNPs in animals using ac susceptometry based on a high-Tc superconducting quantum interference device (SQUID) is presented. The non-invasive results and biopsy results show good agreement, and two gold-standard biomedicine methods, Prussian blue stain and inductively coupled plasma, prove the magnetic results. This confirms that the future clinical diagnosis of bio-functional MNPs could be operated by using scanning SQUID biosusceptometry as conveniently as an ultrasonic probe.",
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