Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation

Tung Lu Kwok, Robin Y.Y. Chiou, Ging Chen Li, Hsiang Chen Ming, Ting Tseng Wan, Tsang Hsieh Hsiang, Ling Yang Yi

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Resveratrol is a natural phytoestrogen and possesses many biological functions such as anti-inflammatory activity and protection against atherosclerosis and myocardial infraction. The present study was carried out to elucidate the neuroprotective effect and possible mechanism of resveratrol on cerebral ischemia-induced hippocampus neuron loss. Sixty adult male rats underwent general anesthesia (urethane, 1.4 g/kg, i.p.) and were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol administration (20 mg/kg, i.v.). The carotid artery was bilaterally ligated to induce cerebral ischemia. Microdialysis and high-performance liquid chromatography were used to analyze dihydroxybenzoic acid (DHBA) that reflected the hippocampal hydroxyl radical level. Hippocampal nitric oxide was assayed among different groups. During cerebral ischemia, the hydroxyl radical levels were elevated in rats and animals displayed severe neuronal loss. A single dose of resveratrol significantly increased the nitric oxide level and decreased the hydroxyl radical level. The reduction of cerebral blood flow and neuronal loss were also attenuated by resveratrol treatment. The results demonstrated that a single infusion of resveratrol could elicit neuroprotective effects on cerebral ischemia-induced neuron damage through free radical scavenging and cerebral blood elevation due to NO release.

Original languageEnglish
Pages (from-to)3126-3131
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume54
Issue number8
DOIs
Publication statusPublished - 2006 Apr 19

Fingerprint

Cerebrovascular Circulation
neuroprotective effect
Scavenging
resveratrol
Neuroprotective Agents
ischemia
Brain Ischemia
blood flow
Neurons
Free Radicals
Blood
neurons
hydroxyl radicals
Hydroxyl Radical
nitric oxide
Rats
Nitric Oxide
Ischemia
urethane
Phytoestrogens

Keywords

  • Free radicals
  • Ischemia
  • Neuronal damage
  • Nitric oxide
  • Phytoestrogen

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation. / Kwok, Tung Lu; Chiou, Robin Y.Y.; Li, Ging Chen; Ming, Hsiang Chen; Wan, Ting Tseng; Hsiang, Tsang Hsieh; Yi, Ling Yang.

In: Journal of Agricultural and Food Chemistry, Vol. 54, No. 8, 19.04.2006, p. 3126-3131.

Research output: Contribution to journalArticle

Kwok, Tung Lu ; Chiou, Robin Y.Y. ; Li, Ging Chen ; Ming, Hsiang Chen ; Wan, Ting Tseng ; Hsiang, Tsang Hsieh ; Yi, Ling Yang. / Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation. In: Journal of Agricultural and Food Chemistry. 2006 ; Vol. 54, No. 8. pp. 3126-3131.
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