Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer - A canine model

Jin Tung Liang, Chiang-Ting Chien, King Jen Chang, Hey Chi Hsu, Shu Hsun Chu, Ming Kuen Lai, Shih Ming Wang, Kai Mo Chen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND/AIMS: The relative contribution and interrelated compensation of sympathetic signals among sympathetic components in pelvic plexus remain undefined. This study was designed to investigate the genitourinary function in response to autonomic nerve preservation and severance using a canine model. METHODOLOGY: Eighteen mongrel dogs were randomly divided into 3 groups which received severance of the hypogastric nerves on either the right side, left side, or on both sides. The hypogastric nerves and sacral sympathetic trunks were electrically stimulated and the contraction pressure of the internal urethral orifice was measured immediately, at 1- and 3-month intervals. The ejaculation function and the length of time required to reach sexual orgasm were evaluated by manual penis-stimulation. RESULTS: The difference between the left and right sides of the normal hypogastric nerve in contribution to sympathetic signals was insignificant. Compared with the hypogastric nerve, the bilateral sacral sympathetic trunks were functionally trivial in controlling the closure of the internal urethral orifice. The preserved side of the hypogastric nerve compensated for the loss of sympathetic signals of the severed side within 1 month and, thereafter, remained stationary. In contrast, the functional compensation of bilateral sacral sympathetic trunks for the severed bilateral hypogastric nerves was insignificant. When the hypogastric nerve was preserved in one or both sides, all dogs maintained normal antegrade ejaculation. If bilateral hypogastric nerves were severed, 50.0% (3/6) of the dogs lost both emission and ejaculation function; 33.3% (2/6) presented with retrograde ejaculation; and, 16.7% (1/6) presented with combined retrograde ejaculation and reduced antegrade ejaculation. The time required to reach sexual orgasm was not affected by the severance of the hypogastric nerve. CONCLUSIONS: The normal genitourinary function could be maintained only when at least one side of the hypogastric nerve was preserved.

Original languageEnglish
Pages (from-to)2206-2214
Number of pages9
JournalHepato-Gastroenterology
Volume45
Issue number24
Publication statusPublished - 1998 Dec 1

Fingerprint

Ejaculation
Rectal Neoplasms
Canidae
Orgasm
Dogs
Hypogastric Plexus
Autonomic Pathways
Penis
Pressure

Keywords

  • Hypogastric nerve
  • Nerve-preserving surgery
  • Rectal cancer
  • Sacral sympathetic trunk
  • Sympathetic nerve

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Liang, J. T., Chien, C-T., Chang, K. J., Hsu, H. C., Chu, S. H., Lai, M. K., ... Chen, K. M. (1998). Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer - A canine model. Hepato-Gastroenterology, 45(24), 2206-2214.

Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer - A canine model. / Liang, Jin Tung; Chien, Chiang-Ting; Chang, King Jen; Hsu, Hey Chi; Chu, Shu Hsun; Lai, Ming Kuen; Wang, Shih Ming; Chen, Kai Mo.

In: Hepato-Gastroenterology, Vol. 45, No. 24, 01.12.1998, p. 2206-2214.

Research output: Contribution to journalArticle

Liang, JT, Chien, C-T, Chang, KJ, Hsu, HC, Chu, SH, Lai, MK, Wang, SM & Chen, KM 1998, 'Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer - A canine model', Hepato-Gastroenterology, vol. 45, no. 24, pp. 2206-2214.
Liang, Jin Tung ; Chien, Chiang-Ting ; Chang, King Jen ; Hsu, Hey Chi ; Chu, Shu Hsun ; Lai, Ming Kuen ; Wang, Shih Ming ; Chen, Kai Mo. / Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer - A canine model. In: Hepato-Gastroenterology. 1998 ; Vol. 45, No. 24. pp. 2206-2214.
@article{c57535493a454af099fac3b9c4ed40ee,
title = "Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer - A canine model",
abstract = "BACKGROUND/AIMS: The relative contribution and interrelated compensation of sympathetic signals among sympathetic components in pelvic plexus remain undefined. This study was designed to investigate the genitourinary function in response to autonomic nerve preservation and severance using a canine model. METHODOLOGY: Eighteen mongrel dogs were randomly divided into 3 groups which received severance of the hypogastric nerves on either the right side, left side, or on both sides. The hypogastric nerves and sacral sympathetic trunks were electrically stimulated and the contraction pressure of the internal urethral orifice was measured immediately, at 1- and 3-month intervals. The ejaculation function and the length of time required to reach sexual orgasm were evaluated by manual penis-stimulation. RESULTS: The difference between the left and right sides of the normal hypogastric nerve in contribution to sympathetic signals was insignificant. Compared with the hypogastric nerve, the bilateral sacral sympathetic trunks were functionally trivial in controlling the closure of the internal urethral orifice. The preserved side of the hypogastric nerve compensated for the loss of sympathetic signals of the severed side within 1 month and, thereafter, remained stationary. In contrast, the functional compensation of bilateral sacral sympathetic trunks for the severed bilateral hypogastric nerves was insignificant. When the hypogastric nerve was preserved in one or both sides, all dogs maintained normal antegrade ejaculation. If bilateral hypogastric nerves were severed, 50.0{\%} (3/6) of the dogs lost both emission and ejaculation function; 33.3{\%} (2/6) presented with retrograde ejaculation; and, 16.7{\%} (1/6) presented with combined retrograde ejaculation and reduced antegrade ejaculation. The time required to reach sexual orgasm was not affected by the severance of the hypogastric nerve. CONCLUSIONS: The normal genitourinary function could be maintained only when at least one side of the hypogastric nerve was preserved.",
keywords = "Hypogastric nerve, Nerve-preserving surgery, Rectal cancer, Sacral sympathetic trunk, Sympathetic nerve",
author = "Liang, {Jin Tung} and Chiang-Ting Chien and Chang, {King Jen} and Hsu, {Hey Chi} and Chu, {Shu Hsun} and Lai, {Ming Kuen} and Wang, {Shih Ming} and Chen, {Kai Mo}",
year = "1998",
month = "12",
day = "1",
language = "English",
volume = "45",
pages = "2206--2214",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "24",

}

TY - JOUR

T1 - Neurophysiological basis of sympathetic nerve-preserving surgery for lower rectal cancer - A canine model

AU - Liang, Jin Tung

AU - Chien, Chiang-Ting

AU - Chang, King Jen

AU - Hsu, Hey Chi

AU - Chu, Shu Hsun

AU - Lai, Ming Kuen

AU - Wang, Shih Ming

AU - Chen, Kai Mo

PY - 1998/12/1

Y1 - 1998/12/1

N2 - BACKGROUND/AIMS: The relative contribution and interrelated compensation of sympathetic signals among sympathetic components in pelvic plexus remain undefined. This study was designed to investigate the genitourinary function in response to autonomic nerve preservation and severance using a canine model. METHODOLOGY: Eighteen mongrel dogs were randomly divided into 3 groups which received severance of the hypogastric nerves on either the right side, left side, or on both sides. The hypogastric nerves and sacral sympathetic trunks were electrically stimulated and the contraction pressure of the internal urethral orifice was measured immediately, at 1- and 3-month intervals. The ejaculation function and the length of time required to reach sexual orgasm were evaluated by manual penis-stimulation. RESULTS: The difference between the left and right sides of the normal hypogastric nerve in contribution to sympathetic signals was insignificant. Compared with the hypogastric nerve, the bilateral sacral sympathetic trunks were functionally trivial in controlling the closure of the internal urethral orifice. The preserved side of the hypogastric nerve compensated for the loss of sympathetic signals of the severed side within 1 month and, thereafter, remained stationary. In contrast, the functional compensation of bilateral sacral sympathetic trunks for the severed bilateral hypogastric nerves was insignificant. When the hypogastric nerve was preserved in one or both sides, all dogs maintained normal antegrade ejaculation. If bilateral hypogastric nerves were severed, 50.0% (3/6) of the dogs lost both emission and ejaculation function; 33.3% (2/6) presented with retrograde ejaculation; and, 16.7% (1/6) presented with combined retrograde ejaculation and reduced antegrade ejaculation. The time required to reach sexual orgasm was not affected by the severance of the hypogastric nerve. CONCLUSIONS: The normal genitourinary function could be maintained only when at least one side of the hypogastric nerve was preserved.

AB - BACKGROUND/AIMS: The relative contribution and interrelated compensation of sympathetic signals among sympathetic components in pelvic plexus remain undefined. This study was designed to investigate the genitourinary function in response to autonomic nerve preservation and severance using a canine model. METHODOLOGY: Eighteen mongrel dogs were randomly divided into 3 groups which received severance of the hypogastric nerves on either the right side, left side, or on both sides. The hypogastric nerves and sacral sympathetic trunks were electrically stimulated and the contraction pressure of the internal urethral orifice was measured immediately, at 1- and 3-month intervals. The ejaculation function and the length of time required to reach sexual orgasm were evaluated by manual penis-stimulation. RESULTS: The difference between the left and right sides of the normal hypogastric nerve in contribution to sympathetic signals was insignificant. Compared with the hypogastric nerve, the bilateral sacral sympathetic trunks were functionally trivial in controlling the closure of the internal urethral orifice. The preserved side of the hypogastric nerve compensated for the loss of sympathetic signals of the severed side within 1 month and, thereafter, remained stationary. In contrast, the functional compensation of bilateral sacral sympathetic trunks for the severed bilateral hypogastric nerves was insignificant. When the hypogastric nerve was preserved in one or both sides, all dogs maintained normal antegrade ejaculation. If bilateral hypogastric nerves were severed, 50.0% (3/6) of the dogs lost both emission and ejaculation function; 33.3% (2/6) presented with retrograde ejaculation; and, 16.7% (1/6) presented with combined retrograde ejaculation and reduced antegrade ejaculation. The time required to reach sexual orgasm was not affected by the severance of the hypogastric nerve. CONCLUSIONS: The normal genitourinary function could be maintained only when at least one side of the hypogastric nerve was preserved.

KW - Hypogastric nerve

KW - Nerve-preserving surgery

KW - Rectal cancer

KW - Sacral sympathetic trunk

KW - Sympathetic nerve

UR - http://www.scopus.com/inward/record.url?scp=0032413843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032413843&partnerID=8YFLogxK

M3 - Article

C2 - 9951896

AN - SCOPUS:0032413843

VL - 45

SP - 2206

EP - 2214

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 24

ER -