Abstract
To determine the contribution of neural elements to micturition, we evaluated, in intact rats, the cystometrogram, pelvic afferent nervous activity, pelvic efferent nervous activity and external urethral sphincter-electromyogram activity in the normal and acute partial bladder outlet obstruction states. In the normal state, in response to saline filling, mechanoreceptor-dependent pelvic afferent nervous activity gradually activated and finally triggered a voiding reflex, including four phases of detrusor contractions. Phase 1 was characterized by an initial rising intravesical pressure, Phase 2 was characterized by a series of high-frequency oscillations in intravesical pressure, Phase 3 contraction was characterized by a rebound intravesical pressure and Phase 4 contraction was characterized by a rapid fall in intravesical pressure. In the acute partial bladder outlet obstruction state, Phase 1 contraction rose and high-frequency oscillations fell in Phase 2. This voiding dysfunction is ascribed to the bursting extraurethral sphincter activity being converted to tonic extraurethral sphincter activity.In summary, the suppressed high-frequency oscillations in Phase 2 of the detrusor muscle contraction could be detrimental to efficient voidings in the acute partial bladder outlet obstructed rat. Copyright (C) 1999 IBRO.
| Original language | English |
|---|---|
| Pages (from-to) | 221-230 |
| Number of pages | 10 |
| Journal | Neuroscience |
| Volume | 96 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2000 Jan 1 |
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Keywords
- Bladder outlet obstruction
- Cholinergic
- High-frequency oscillation
- Pelvic nerve
- Purinergic
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neural mechanisms of impaired micturition reflex in rats with acute partial bladder outlet obstruction. / Chien, Chiang-Ting; Yu, H. J.; Lin, T. B.; Chen, C. F.
In: Neuroscience, Vol. 96, No. 1, 01.01.2000, p. 221-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neural mechanisms of impaired micturition reflex in rats with acute partial bladder outlet obstruction
AU - Chien, Chiang-Ting
AU - Yu, H. J.
AU - Lin, T. B.
AU - Chen, C. F.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - To determine the contribution of neural elements to micturition, we evaluated, in intact rats, the cystometrogram, pelvic afferent nervous activity, pelvic efferent nervous activity and external urethral sphincter-electromyogram activity in the normal and acute partial bladder outlet obstruction states. In the normal state, in response to saline filling, mechanoreceptor-dependent pelvic afferent nervous activity gradually activated and finally triggered a voiding reflex, including four phases of detrusor contractions. Phase 1 was characterized by an initial rising intravesical pressure, Phase 2 was characterized by a series of high-frequency oscillations in intravesical pressure, Phase 3 contraction was characterized by a rebound intravesical pressure and Phase 4 contraction was characterized by a rapid fall in intravesical pressure. In the acute partial bladder outlet obstruction state, Phase 1 contraction rose and high-frequency oscillations fell in Phase 2. This voiding dysfunction is ascribed to the bursting extraurethral sphincter activity being converted to tonic extraurethral sphincter activity.In summary, the suppressed high-frequency oscillations in Phase 2 of the detrusor muscle contraction could be detrimental to efficient voidings in the acute partial bladder outlet obstructed rat. Copyright (C) 1999 IBRO.
AB - To determine the contribution of neural elements to micturition, we evaluated, in intact rats, the cystometrogram, pelvic afferent nervous activity, pelvic efferent nervous activity and external urethral sphincter-electromyogram activity in the normal and acute partial bladder outlet obstruction states. In the normal state, in response to saline filling, mechanoreceptor-dependent pelvic afferent nervous activity gradually activated and finally triggered a voiding reflex, including four phases of detrusor contractions. Phase 1 was characterized by an initial rising intravesical pressure, Phase 2 was characterized by a series of high-frequency oscillations in intravesical pressure, Phase 3 contraction was characterized by a rebound intravesical pressure and Phase 4 contraction was characterized by a rapid fall in intravesical pressure. In the acute partial bladder outlet obstruction state, Phase 1 contraction rose and high-frequency oscillations fell in Phase 2. This voiding dysfunction is ascribed to the bursting extraurethral sphincter activity being converted to tonic extraurethral sphincter activity.In summary, the suppressed high-frequency oscillations in Phase 2 of the detrusor muscle contraction could be detrimental to efficient voidings in the acute partial bladder outlet obstructed rat. Copyright (C) 1999 IBRO.
KW - Bladder outlet obstruction
KW - Cholinergic
KW - High-frequency oscillation
KW - Pelvic nerve
KW - Purinergic
UR - http://www.scopus.com/inward/record.url?scp=0033961761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033961761&partnerID=8YFLogxK
U2 - 10.1016/S0306-4522(99)00508-4
DO - 10.1016/S0306-4522(99)00508-4
M3 - Article
C2 - 10683426
AN - SCOPUS:0033961761
VL - 96
SP - 221
EP - 230
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 1
ER -