NBS as an efficient catalyst for the synthesis of 1,5-benzodiazepine derivatives under mild conditions

Chun Wei Kuo, Shivaji V. More, Ching Fa Yao

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53 Citations (Scopus)


Various biologically important 1,5-benzodiazepine derivatives were efficiently synthesized in excellent yields using catalytic amounts of NBS (10 mol %). This inexpensive, nontoxic, and readily available catalyst efficiently catalyzes the condensation of several aromatic as well as aliphatic ketones with substituted o-phenylenediamines.

Original languageEnglish
Pages (from-to)8523-8528
Number of pages6
JournalTetrahedron Letters
Issue number48
Publication statusPublished - 2006 Nov 27


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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