NBS as an efficient catalyst for the synthesis of 1,5-benzodiazepine derivatives under mild conditions

Chun Wei Kuo, Shivaji V. More, Ching-Fa Yao

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Various biologically important 1,5-benzodiazepine derivatives were efficiently synthesized in excellent yields using catalytic amounts of NBS (10 mol %). This inexpensive, nontoxic, and readily available catalyst efficiently catalyzes the condensation of several aromatic as well as aliphatic ketones with substituted o-phenylenediamines.

Original languageEnglish
Pages (from-to)8523-8528
Number of pages6
JournalTetrahedron Letters
Volume47
Issue number48
DOIs
Publication statusPublished - 2006 Nov 27

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Ketones
Benzodiazepines
Condensation
Derivatives
Catalysts
1,2-diaminobenzene

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

NBS as an efficient catalyst for the synthesis of 1,5-benzodiazepine derivatives under mild conditions. / Kuo, Chun Wei; More, Shivaji V.; Yao, Ching-Fa.

In: Tetrahedron Letters, Vol. 47, No. 48, 27.11.2006, p. 8523-8528.

Research output: Contribution to journalArticle

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