Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells

Medicine & Life Sciences

• THP-1 Cells 100%
• Flavonoids 82%
• Glucose 51%
• Cytokines 50%
• Monocytes 40%
• N(6)-carboxymethyllysine 24%
• Luteolin 22%
• Rutin 22%
• Receptor for Advanced Glycation End Products 21%
• Catechin 20%
• Advanced Glycation End Products 19%
• Inflammation 19%
• Quercetin 18%
• NADPH Oxidases 18%
• Extracellular Signal-Regulated MAP Kinases 17%
• Phytochemicals 17%
• Cyclooxygenase 2 17%
• p38 Mitogen-Activated Protein Kinases 16%
• Interleukin-1 16%
• Protein Kinases 15%
• Hyperglycemia 14%
• Atherosclerosis 13%
• Reactive Oxygen Species 13%
• Antioxidants 12%
• Anti-Inflammatory Agents 12%
• Proteins 12%
• Oxidative Stress 11%
• Down-Regulation 11%
• Phosphorylation 11%
• Messenger RNA 9%

Agriculture & Biology

• cytokines 76%
• flavonoids 63%
• monocytes 51%
• glucose 49%
• mitogen-activated protein kinase 35%
• inflammation 29%
• cells 25%
• advanced glycation end products 23%
• hyperglycemia 19%
• NAD(P)H oxidase (H2O2-forming) 19%
• luteolin 19%
• interleukin-1 19%
• atherosclerosis 18%
• prostaglandin synthase 18%
• catechin 17%
• rutin 17%
• anti-inflammatory activity 17%
• quercetin 15%
• protein kinases 15%
• protective effect 15%
• phytochemicals 14%
• phosphorylation 14%
• lysine 13%
• reactive oxygen species 13%
• oxidative stress 12%
• protein synthesis 12%
• antioxidant activity 11%
• receptors 11%
• gene expression 9%
• proteins 5%