@article{11feb41aabf7408fba5b52f6f0c43b63,
title = "Nationwide population-based cohort study on the association of acute coronary syndrome in patients with malignancies",
abstract = "Aims/introduction: Patients with malignancy are suggestive of having a tendency toward an association with vascular thrombosis risk. The aim of this study was to evaluate the possible relationship between malignancy and the risk of acute coronary syndrome (ACS) in Taiwan.Materials and methods: We used data from the National Health Insurance (NHI) system of Taiwan to assess the issue. Cox proportional hazards regression analysis was conducted to estimate the effects of malignancy on the risk of ACS.Results: ACS risk in patients with malignancies was marginally significantly greater when adjusted for age, sex (hazard ratio (HR) = 1.09, 95 % confidence interval (CI) = 0.99–1.20), and comorbidities (HR = 1.03, 95 % CI = 0.93–1.13). A subgroup analysis indicated that patients with prostate cancer and head and neck cancer (HEENT) had a significantly higher risk of ACS (HR = 1.30, 95 % CI = 1.01–1.67; HR = 3.03, 95 % CI = 1.47–6.50).Conclusions: We suggest careful surveillance of ACS symptoms and regular electrocardiography during follow-up of these patients. However, further large-scale studies for patients with prostate and HEENT cancer and cancer survivors (especially from post-hormone or radiotherapy) are needed.",
keywords = "Acute coronary syndrome, Malignancy, Population-based cohort study",
author = "Lin, {Yen Nien} and Chang, {Yen Jung} and Chen, {Yin Huei} and Ko, {Po Yen} and Lin, {Cheng Li} and Sung, {Fung Chang} and Chang, {Kuan Cheng} and Kao, {Chia Hung}",
note = "Funding Information: and complex clinical statuses, which usually render them ineligible for clinical studies. However, current experience from the real world derived mostly from small population and regional studies of select cancer diseases is not devoid of bias. The National Health Insurance (NHI) system in Taiwan was sponsored by the National Health Insurance Bureau, Department of Health, since March 1995. The National Health Research Institute computerized the NHI data into several data sets to facilitate research. This retrospective cohort study was rendered possible with the NHIRD. To the best of our knowledge, this is the first nationwide and largest population study to associate the risk of ACS following malignancy development. Funding Information: Acknowledgments This work was supported by the study projects (DMR-102-014 and DMR-102-023) in our hospital; Taiwan Ministry of Health and Welfare Clinical Trial and Research Center for Excellence (DOH102-TD-B-111-004); Taiwan Ministry of Health and Welfare Cancer Research Center for Excellence (MOHW103-TD-B-111-03); and the International Research-Intensive Centers of Excellence in Taiwan (I-RiCE) (NSC101-2911-I-002-303). Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",
year = "2014",
month = oct,
doi = "10.1007/s00520-014-2262-8",
language = "English",
volume = "22",
pages = "2707--2713",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer Verlag",
number = "10",
}
