Nanoscale imaging of biomolecules by controlled carbon nanotube probes

Yuan Chih Chang, Chia Seng Chang*, Dau Chung Wang, Ming Hui Lee, Ting Fang Wang, Mei Yueh Wu, Tsu Yi Fu, Tien T. Tsong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We use a carbon nanotube (CNT) probe to observe the details in double-stranded deoxyribonucleic acid (DNA) and proteins under atomic force microscopy (AFM) tapping mode in air. The DNA has periodic helical turns of approximately 4 nm interval. Fine ring like and helical structures in the proteins adsorbed on graphite have also been resolved. These results cannot be reproduced using conventional AFM silicon probes. The superiority of the CNT probe applied with the AFM tapping mode lies in both the unique mechanical and chemical properties of the carbon nanotube, and in our ability to tailor the length and adjust the angle of the CNT probe attached to a commercial AFM tip.

Original languageEnglish
Pages (from-to)4517-4520
Number of pages4
JournalJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
Issue number7 B
Publication statusPublished - 2004 Jul


  • Atomic force microscopy
  • Carbon nanotube
  • DNA
  • Protein

ASJC Scopus subject areas

  • General Engineering
  • General Physics and Astronomy


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