Nanomagnetic particles for SQUID-based magnetically labeled immunoassay

H. E. Horng, S. Y. Yang, Y. W. Huang, W. Q. Jiang, C. Y. Hong, H. C. Yang

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

With the increasing importance of SQUID-based magnetically labeled immunoassay, the study on the synthesis of controllable sizes of magnetic nanoparticles plays a role to promote the accuracy of the immunoassay. In this work, Fe3O4 nano-particles coated with a suitable bio-probe (biotin) are synthesized through chemical co-precipitation process to probe the bio-target (avidin). Through the synthesis developed here, the particle hydrodynamic diameter can be adjusted from 30 to 90 nm, which provide candidates for probing various bio-targets in the future. The amount of the magnetically labeled avidin is then analyzed via measuring the saturated magnetization or the remanence of the sample by using a SQUID magnetometer.

Original languageEnglish
Pages (from-to)668-671
Number of pages4
JournalIEEE Transactions on Applied Superconductivity
Volume15
Issue number2 PART I
DOIs
Publication statusPublished - 2005 Jun 1

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Keywords

  • Immunoassay
  • Nanomagnetic particles
  • SQUIDs

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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