Nanomagnetic particles for SQUID-based magnetically labeled immunoassay

H. E. Horng, S. Y. Yang, Y. W. Huang, W. Q. Jiang, C. Y. Hong, H. C. Yang

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)

    Abstract

    With the increasing importance of SQUID-based magnetically labeled immunoassay, the study on the synthesis of controllable sizes of magnetic nanoparticles plays a role to promote the accuracy of the immunoassay. In this work, Fe3O4 nano-particles coated with a suitable bio-probe (biotin) are synthesized through chemical co-precipitation process to probe the bio-target (avidin). Through the synthesis developed here, the particle hydrodynamic diameter can be adjusted from 30 to 90 nm, which provide candidates for probing various bio-targets in the future. The amount of the magnetically labeled avidin is then analyzed via measuring the saturated magnetization or the remanence of the sample by using a SQUID magnetometer.

    Original languageEnglish
    Pages (from-to)668-671
    Number of pages4
    JournalIEEE Transactions on Applied Superconductivity
    Volume15
    Issue number2 PART I
    DOIs
    Publication statusPublished - 2005 Jun 1

    Keywords

    • Immunoassay
    • Nanomagnetic particles
    • SQUIDs

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Electrical and Electronic Engineering

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