Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic alzheimer's mice

Hei Jen Huang, Wei Lin Chen, Rong Hong Hsieh, Hsiu Mei Hsieh-Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Mangosteen- (Garcinia mangostana-) based nutraceutical compounds have long been reported to possess multiple health-promoting properties. The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC). We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice. After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phosphotau S202) in older B6 mice. We further applied MP dietary supplementation to triple transgenic Alzheimer's disease (3xTg-AD) mice from 5 to 13 months old. The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the Aβ deposition and p-tau (S202/S262) levels in the hippocampus of 3xTg-AD mice, which might further attenuate the deficit in spatial memory retrieval. Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD.

Original languageEnglish
Article number813672
JournalEvidence-based Complementary and Alternative Medicine
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Complementary and alternative medicine


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