Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

M. J. Chiu; Herng-Er Horng; J. J. Chieh; S. H. Liao; C. H. Chen; B. Y. Shih; C. C. Yang; C. L. Lee; T. F. Chen; Shieh-Yueh Yang; C. Y. Hong; Hong-Chang Yang

doi:10.1109/TASC.2010.2087304

Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

M. J. Chiu, Herng-Er Horng, J. J. Chieh, S. H. Liao, C. H. Chen, B. Y. Shih, C. C. Yang, C. L. Lee, T. F. Chen, Shieh-Yueh Yang, C. Y. Hong, Hong-Chang Yang

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38 Citations (Scopus)

Abstract

Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

Original language	English
Article number	5634078
Pages (from-to)	477-480
Number of pages	4
Journal	IEEE Transactions on Applied Superconductivity
Volume	21
Issue number	3 PART 1
DOIs	https://doi.org/10.1109/TASC.2010.2087304
Publication status	Published - 2011 Jun

Keywords

Alzheimer's disease
Immunoassay
Magnetic nanoparticles
SQUIDs

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

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10.1109/TASC.2010.2087304

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Chiu, M. J., Horng, H-E., Chieh, J. J., Liao, S. H., Chen, C. H., Shih, B. Y., Yang, C. C., Lee, C. L., Chen, T. F., Yang, S-Y., Hong, C. Y., & Yang, H-C. (2011). Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction. IEEE Transactions on Applied Superconductivity, 21(3 PART 1), 477-480. [5634078]. https://doi.org/10.1109/TASC.2010.2087304

Chiu, MJ, Horng, H-E , Chieh, JJ , Liao, SH, Chen, CH, Shih, BY, Yang, CC, Lee, CL, Chen, TF, Yang, S-Y, Hong, CY & Yang, H-C 2011, 'Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction', IEEE Transactions on Applied Superconductivity, vol. 21, no. 3 PART 1, 5634078, pp. 477-480. https://doi.org/10.1109/TASC.2010.2087304

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title = "Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction",

abstract = "Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.",

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author = "Chiu, {M. J.} and Herng-Er Horng and Chieh, {J. J.} and Liao, {S. H.} and Chen, {C. H.} and Shih, {B. Y.} and Yang, {C. C.} and Lee, {C. L.} and Chen, {T. F.} and Shieh-Yueh Yang and Hong, {C. Y.} and Hong-Chang Yang",

note = "Funding Information: Manuscript received August 02, 2010; accepted October 06, 2010. Date of publication November 11, 2010; date of current version May 27, 2011. This work was supported by the National Science Council of Taiwan under Grants 98-2112-M-003-003, 98-2323-B-003-001-CC2, and NSC98-2752-M-002-016-PAE, and by the Ministry of Economic Affairs of Taiwan under Grants 1Z970688 (SBIR) and S09800226-203 (JAID), and by the Department of Health under Grants DOH98-TD-N-111-008 and DOH99-TD-N-111-008.",

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AU - Chieh, J. J.

AU - Liao, S. H.

AU - Chen, C. H.

AU - Shih, B. Y.

AU - Yang, C. C.

AU - Lee, C. L.

AU - Chen, T. F.

AU - Yang, Shieh-Yueh

AU - Hong, C. Y.

AU - Yang, Hong-Chang

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N2 - Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

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Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

Abstract

Keywords

ASJC Scopus subject areas

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