Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

M. J. Chiu; H. E. Horng; J. J. Chieh; S. H. Liao; C. H. Chen; B. Y. Shih; C. C. Yang; C. L. Lee; T. F. Chen; S. Y. Yang; C. Y. Hong; H. C. Yang

doi:10.1109/TASC.2010.2087304

Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

M. J. Chiu, H. E. Horng, J. J. Chieh, S. H. Liao, C. H. Chen, B. Y. Shih, C. C. Yang, C. L. Lee, T. F. Chen, S. Y. Yang, C. Y. Hong, H. C. Yang

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

Original language	English
Article number	5634078
Pages (from-to)	477-480
Number of pages	4
Journal	IEEE Transactions on Applied Superconductivity
Volume	21
Issue number	3 PART 1
DOIs	https://doi.org/10.1109/TASC.2010.2087304
Publication status	Published - 2011 Jun

Keywords

Alzheimer's disease
Immunoassay
Magnetic nanoparticles
SQUIDs

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

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10.1109/TASC.2010.2087304

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Chiu, M. J., Horng, H. E., Chieh, J. J., Liao, S. H., Chen, C. H., Shih, B. Y., Yang, C. C., Lee, C. L., Chen, T. F., Yang, S. Y., Hong, C. Y., & Yang, H. C. (2011). Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction. IEEE Transactions on Applied Superconductivity, 21(3 PART 1), 477-480. Article 5634078. https://doi.org/10.1109/TASC.2010.2087304

Chiu, MJ, Horng, HE , Chieh, JJ , Liao, SH, Chen, CH, Shih, BY, Yang, CC, Lee, CL, Chen, TF, Yang, SY, Hong, CY & Yang, HC 2011, 'Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction', IEEE Transactions on Applied Superconductivity, vol. 21, no. 3 PART 1, 5634078, pp. 477-480. https://doi.org/10.1109/TASC.2010.2087304

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title = "Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction",

abstract = "Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.",

keywords = "Alzheimer's disease, Immunoassay, Magnetic nanoparticles, SQUIDs",

author = "Chiu, {M. J.} and Horng, {H. E.} and Chieh, {J. J.} and Liao, {S. H.} and Chen, {C. H.} and Shih, {B. Y.} and Yang, {C. C.} and Lee, {C. L.} and Chen, {T. F.} and Yang, {S. Y.} and Hong, {C. Y.} and Yang, {H. C.}",

note = "Funding Information: Manuscript received August 02, 2010; accepted October 06, 2010. Date of publication November 11, 2010; date of current version May 27, 2011. This work was supported by the National Science Council of Taiwan under Grants 98-2112-M-003-003, 98-2323-B-003-001-CC2, and NSC98-2752-M-002-016-PAE, and by the Ministry of Economic Affairs of Taiwan under Grants 1Z970688 (SBIR) and S09800226-203 (JAID), and by the Department of Health under Grants DOH98-TD-N-111-008 and DOH99-TD-N-111-008.",

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AU - Horng, H. E.

AU - Chieh, J. J.

AU - Liao, S. H.

AU - Chen, C. H.

AU - Shih, B. Y.

AU - Yang, C. C.

AU - Lee, C. L.

AU - Chen, T. F.

AU - Yang, S. Y.

AU - Hong, C. Y.

AU - Yang, H. C.

N1 - Funding Information: Manuscript received August 02, 2010; accepted October 06, 2010. Date of publication November 11, 2010; date of current version May 27, 2011. This work was supported by the National Science Council of Taiwan under Grants 98-2112-M-003-003, 98-2323-B-003-001-CC2, and NSC98-2752-M-002-016-PAE, and by the Ministry of Economic Affairs of Taiwan under Grants 1Z970688 (SBIR) and S09800226-203 (JAID), and by the Department of Health under Grants DOH98-TD-N-111-008 and DOH99-TD-N-111-008.

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N2 - Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

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Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

Abstract

Keywords

ASJC Scopus subject areas

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