Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

M. J. Chiu, H. E. Horng, J. J. Chieh, S. H. Liao, C. H. Chen, B. Y. Shih, C. C. Yang, C. L. Lee, T. F. Chen, S. Y. Yang, C. Y. Hong, H. C. Yang

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

    Original languageEnglish
    Article number5634078
    Pages (from-to)477-480
    Number of pages4
    JournalIEEE Transactions on Applied Superconductivity
    Volume21
    Issue number3 PART 1
    DOIs
    Publication statusPublished - 2011 Jun 1

    Keywords

    • Alzheimer's disease
    • Immunoassay
    • Magnetic nanoparticles
    • SQUIDs

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Electrical and Electronic Engineering

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