Multi-channel squid-based ultra-high-sensitivity in-vitro detections for bio-markers of alzheimer's disease via immunomagnetic reduction

M. J. Chiu, H. E. Horng, J. J. Chieh, S. H. Liao, C. H. Chen, B. Y. Shih, C. C. Yang, C. L. Lee, T. F. Chen, S. Y. Yang, C. Y. Hong, H. C. Yang

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

Original languageEnglish
Article number5634078
Pages (from-to)477-480
Number of pages4
JournalIEEE Transactions on Applied Superconductivity
Volume21
Issue number3 PART 1
DOIs
Publication statusPublished - 2011 Jun 1

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Keywords

  • Alzheimer's disease
  • Immunoassay
  • Magnetic nanoparticles
  • SQUIDs

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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