Monitoring protein-related degeneration of Drosophila eyes with optical coherence tomography

Chia Heng Wu, Cihun Siyong Alex Gong, Min Tsan Su, Meng Tsan Tsai

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Drosophila melanogaster has become an invertebrate genetic model for studies of genes-related diseases and developmental biology. Neurodegenerative diseases such Alzheimer and Parkinson's diseases are health problem and get worse with age. However, the causes and progress of neurodegenerative diseases are still poorly understood. The compound eye of Drosophila demonstrates a heterologous system to investigate neurodegenerative diseases. In this study, we propose to use optical coherence tomography (OCT) for the study of protein-related degeneration of Drosophila eyes. With OCT, the bristles of Drosophila eye can be identified and different mutant Drosophila were scanned with OCT for investigation of progress of protein-related degeneration. From the results, it can be noted that OCT could be a powerful and noninvasive inspection tool for protein-related degenerative diseases.

Original languageEnglish
Title of host publicationBiomedical Imaging and Sensing Conference
EditorsToyohiko Yatagai, Yoshihisa Aizu, Osamu Matoba, Yasuhiro Awatsuji, Yuan Luo
ISBN (Electronic)9781510619791
Publication statusPublished - 2018
EventBiomedical Imaging and Sensing Conference 2018 - Yokohama, Japan
Duration: 2018 Apr 252018 Apr 27

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceBiomedical Imaging and Sensing Conference 2018

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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