Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy

Wen Lo; Chien Hsin Tso; Pei Yue Huang; Chih Lung Hsu; Chun Chia Yeh; Sung Jan Lin; Shiou Hwa Jee; Chia Chun Chen; Chen Yuan Dong

Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy

Wen Lo, Chien Hsin Tso, Pei Yue Huang, Chih Lung Hsu, Chun Chia Yeh, Sung Jan Lin, Shiou Hwa Jee, Chia Chun Chen, Chen Yuan Dong^*

^*Corresponding author for this work

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Luminescent quantum dots (QDs) are attractive fluorescent probes in bioimaging application. In this work, we investigate the feasibility of administering QDs (7 nm in size) through transdermal delivery pathway using multiphoton fluorescence imaging. Our results show that QDs of this size range can be effectively delivered through intercellular pathways using the chemical enhancer oleic acid. This work has implications for understanding the transport of important biological macromolecules. Our results suggest that QDs can be non-invasively delivered for biological imaging and for probing the transport of nanometer-scale material in tissue. These results also imply that the size of nanoparticles may dominate the nature of transdermal transport mechanism.

Original language	English
Title of host publication	Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004
Pages	74-75
Number of pages	2
Publication status	Published - 2004
Event	Second Asian and Pacific Rim Symposium on Biophotonics, APBP 2004 - Taipei, Taiwan Duration: 2004 Dec 15 → 2004 Dec 17

Publication series

Name	Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004

Other

Other	Second Asian and Pacific Rim Symposium on Biophotonics, APBP 2004
Country/Territory	Taiwan
City	Taipei
Period	2004/12/15 → 2004/12/17

ASJC Scopus subject areas

General Engineering

Cite this

Lo, W., Tso, C. H., Huang, P. Y., Hsu, C. L., Yeh, C. C., Lin, S. J., Jee, S. H., Chen, C. C., & Dong, C. Y. (2004). Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy. In Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004 (pp. 74-75). (Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004).

Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy. / Lo, Wen; Tso, Chien Hsin; Huang, Pei Yue et al.
Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004. 2004. p. 74-75 (Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lo, W, Tso, CH, Huang, PY, Hsu, CL, Yeh, CC, Lin, SJ, Jee, SH, Chen, CC & Dong, CY 2004, Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy. in Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004. Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004, pp. 74-75, Second Asian and Pacific Rim Symposium on Biophotonics, APBP 2004, Taipei, Taiwan, 2004/12/15.

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title = "Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy",

abstract = "Luminescent quantum dots (QDs) are attractive fluorescent probes in bioimaging application. In this work, we investigate the feasibility of administering QDs (7 nm in size) through transdermal delivery pathway using multiphoton fluorescence imaging. Our results show that QDs of this size range can be effectively delivered through intercellular pathways using the chemical enhancer oleic acid. This work has implications for understanding the transport of important biological macromolecules. Our results suggest that QDs can be non-invasively delivered for biological imaging and for probing the transport of nanometer-scale material in tissue. These results also imply that the size of nanoparticles may dominate the nature of transdermal transport mechanism.",

author = "Wen Lo and Tso, {Chien Hsin} and Huang, {Pei Yue} and Hsu, {Chih Lung} and Yeh, {Chun Chia} and Lin, {Sung Jan} and Jee, {Shiou Hwa} and Chen, {Chia Chun} and Dong, {Chen Yuan}",

year = "2004",

language = "English",

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series = "Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004",

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note = "Second Asian and Pacific Rim Symposium on Biophotonics, APBP 2004 ; Conference date: 15-12-2004 Through 17-12-2004",

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T1 - Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy

AU - Lo, Wen

AU - Tso, Chien Hsin

AU - Huang, Pei Yue

AU - Hsu, Chih Lung

AU - Yeh, Chun Chia

AU - Lin, Sung Jan

AU - Jee, Shiou Hwa

AU - Chen, Chia Chun

AU - Dong, Chen Yuan

PY - 2004

Y1 - 2004

N2 - Luminescent quantum dots (QDs) are attractive fluorescent probes in bioimaging application. In this work, we investigate the feasibility of administering QDs (7 nm in size) through transdermal delivery pathway using multiphoton fluorescence imaging. Our results show that QDs of this size range can be effectively delivered through intercellular pathways using the chemical enhancer oleic acid. This work has implications for understanding the transport of important biological macromolecules. Our results suggest that QDs can be non-invasively delivered for biological imaging and for probing the transport of nanometer-scale material in tissue. These results also imply that the size of nanoparticles may dominate the nature of transdermal transport mechanism.

AB - Luminescent quantum dots (QDs) are attractive fluorescent probes in bioimaging application. In this work, we investigate the feasibility of administering QDs (7 nm in size) through transdermal delivery pathway using multiphoton fluorescence imaging. Our results show that QDs of this size range can be effectively delivered through intercellular pathways using the chemical enhancer oleic acid. This work has implications for understanding the transport of important biological macromolecules. Our results suggest that QDs can be non-invasively delivered for biological imaging and for probing the transport of nanometer-scale material in tissue. These results also imply that the size of nanoparticles may dominate the nature of transdermal transport mechanism.

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SN - 0780386760

T3 - Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004

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BT - Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004

T2 - Second Asian and Pacific Rim Symposium on Biophotonics, APBP 2004

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Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy

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