Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy

Wen Lo, Chien Hsin Tso, Pei Yue Huang, Chih Lung Hsu, Chun Chia Yeh, Sung Jan Lin, Shiou Hwa Jee, Chia Chun Chen, Chen Yuan Dong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Luminescent quantum dots (QDs) are attractive fluorescent probes in bioimaging application. In this work, we investigate the feasibility of administering QDs (7 nm in size) through transdermal delivery pathway using multiphoton fluorescence imaging. Our results show that QDs of this size range can be effectively delivered through intercellular pathways using the chemical enhancer oleic acid. This work has implications for understanding the transport of important biological macromolecules. Our results suggest that QDs can be non-invasively delivered for biological imaging and for probing the transport of nanometer-scale material in tissue. These results also imply that the size of nanoparticles may dominate the nature of transdermal transport mechanism.

Original languageEnglish
Title of host publicationSecond Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004
Pages74-75
Number of pages2
Publication statusPublished - 2004 Dec 1
EventSecond Asian and Pacific Rim Symposium on Biophotonics, APBP 2004 - Taipei, Taiwan
Duration: 2004 Dec 152004 Dec 17

Publication series

NameSecond Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004

Other

OtherSecond Asian and Pacific Rim Symposium on Biophotonics, APBP 2004
CountryTaiwan
CityTaipei
Period04/12/1504/12/17

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Lo, W., Tso, C. H., Huang, P. Y., Hsu, C. L., Yeh, C. C., Lin, S. J., Jee, S. H., Chen, C. C., & Dong, C. Y. (2004). Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy. In Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004 (pp. 74-75). (Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004).