Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4- dihydropyridine derivatives via Hantzsch reaction

Shengkai Ko; M. N.V. Sastry; Chunchi Lin; Ching Fa Yao

doi:10.1016/j.tetlet.2005.05.148

Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4- dihydropyridine derivatives via Hantzsch reaction

Shengkai Ko, M. N.V. Sastry, Chunchi Lin, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

356 Citations (Scopus)

Abstract

A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridine derivatives at room temperature using catalytic amount of iodine were reported with excellent product yields. An easy access to various substituted 1,4-dihydropyridine derivatives quantitatively using commercially available iodine as a catalyst.

Original language	English
Pages (from-to)	5771-5774
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	34
DOIs	https://doi.org/10.1016/j.tetlet.2005.05.148
Publication status	Published - 2005 Aug 22

Keywords

Catalytic amounts
Hantzsch reaction
Molecular iodine
Simple and efficient
Synthesis of 1,4-dihydropyridine

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.05.148

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title = "Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4- dihydropyridine derivatives via Hantzsch reaction",

abstract = "A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridine derivatives at room temperature using catalytic amount of iodine were reported with excellent product yields. An easy access to various substituted 1,4-dihydropyridine derivatives quantitatively using commercially available iodine as a catalyst.",

keywords = "Catalytic amounts, Hantzsch reaction, Molecular iodine, Simple and efficient, Synthesis of 1,4-dihydropyridine",

author = "Shengkai Ko and Sastry, {M. N.V.} and Chunchi Lin and Yao, {Ching Fa}",

note = "Funding Information: Financial support of this work by the National Science Council of the Republic of China and National Taiwan Normal University (ORD93-C) is gratefully acknowledged. ",

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doi = "10.1016/j.tetlet.2005.05.148",

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T1 - Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4- dihydropyridine derivatives via Hantzsch reaction

AU - Ko, Shengkai

AU - Sastry, M. N.V.

AU - Lin, Chunchi

AU - Yao, Ching Fa

N1 - Funding Information: Financial support of this work by the National Science Council of the Republic of China and National Taiwan Normal University (ORD93-C) is gratefully acknowledged.

PY - 2005/8/22

Y1 - 2005/8/22

N2 - A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridine derivatives at room temperature using catalytic amount of iodine were reported with excellent product yields. An easy access to various substituted 1,4-dihydropyridine derivatives quantitatively using commercially available iodine as a catalyst.

AB - A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridine derivatives at room temperature using catalytic amount of iodine were reported with excellent product yields. An easy access to various substituted 1,4-dihydropyridine derivatives quantitatively using commercially available iodine as a catalyst.

KW - Catalytic amounts

KW - Hantzsch reaction

KW - Molecular iodine

KW - Simple and efficient

KW - Synthesis of 1,4-dihydropyridine

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DO - 10.1016/j.tetlet.2005.05.148

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4- dihydropyridine derivatives via Hantzsch reaction

Abstract

Keywords

ASJC Scopus subject areas

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