Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4- dihydropyridine derivatives via Hantzsch reaction

Shengkai Ko, M. N.V. Sastry, Chunchi Lin, Ching Fa Yao

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A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridine derivatives at room temperature using catalytic amount of iodine were reported with excellent product yields. An easy access to various substituted 1,4-dihydropyridine derivatives quantitatively using commercially available iodine as a catalyst.

Original languageEnglish
Pages (from-to)5771-5774
Number of pages4
JournalTetrahedron Letters
Issue number34
Publication statusPublished - 2005 Aug 22



  • Catalytic amounts
  • Hantzsch reaction
  • Molecular iodine
  • Simple and efficient
  • Synthesis of 1,4-dihydropyridine

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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