Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines

Shivaji V. More; M. N.V. Sastry; Chieh Chieh Wang; Ching Fa Yao

doi:10.1016/j.tetlet.2005.07.026

Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines

Shivaji V. More, M. N.V. Sastry, Chieh Chieh Wang, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

252 Citations (Scopus)

Abstract

Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields using inexpensive, nontoxic, and readily available bench top chemical, iodine in catalytic amount (10 mol %). Besides this, a systematic study was carried out to evaluate parameters such as solvent and catalyst loading. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines, such as substituted phenylene diamines, tetra amines were further subjected to condensation using catalytic amounts of iodine to afford the products in excellent yield.

Original language	English
Pages (from-to)	6345-6348
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	37
DOIs	https://doi.org/10.1016/j.tetlet.2005.07.026
Publication status	Published - 2005 Sept 12

Keywords

1,2-Diketones
Catalytic amount
Ecofriendly process
Iodine
Quinoxalines

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.07.026

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title = "Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines",

abstract = "Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields using inexpensive, nontoxic, and readily available bench top chemical, iodine in catalytic amount (10 mol %). Besides this, a systematic study was carried out to evaluate parameters such as solvent and catalyst loading. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines, such as substituted phenylene diamines, tetra amines were further subjected to condensation using catalytic amounts of iodine to afford the products in excellent yield.",

keywords = "1,2-Diketones, Catalytic amount, Ecofriendly process, Iodine, Quinoxalines",

author = "More, {Shivaji V.} and Sastry, {M. N.V.} and Wang, {Chieh Chieh} and Yao, {Ching Fa}",

note = "Funding Information: Financial support of this work was provided by the National Science Council of the Republic of China and National Taiwan Normal University (ORD93-C) is gratefully acknowledged. ",

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T2 - A powerful catalyst for the easy and efficient synthesis of quinoxalines

AU - More, Shivaji V.

AU - Sastry, M. N.V.

AU - Wang, Chieh Chieh

AU - Yao, Ching Fa

N1 - Funding Information: Financial support of this work was provided by the National Science Council of the Republic of China and National Taiwan Normal University (ORD93-C) is gratefully acknowledged.

PY - 2005/9/12

Y1 - 2005/9/12

N2 - Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields using inexpensive, nontoxic, and readily available bench top chemical, iodine in catalytic amount (10 mol %). Besides this, a systematic study was carried out to evaluate parameters such as solvent and catalyst loading. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines, such as substituted phenylene diamines, tetra amines were further subjected to condensation using catalytic amounts of iodine to afford the products in excellent yield.

AB - Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields using inexpensive, nontoxic, and readily available bench top chemical, iodine in catalytic amount (10 mol %). Besides this, a systematic study was carried out to evaluate parameters such as solvent and catalyst loading. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines, such as substituted phenylene diamines, tetra amines were further subjected to condensation using catalytic amounts of iodine to afford the products in excellent yield.

KW - 1,2-Diketones

KW - Catalytic amount

KW - Ecofriendly process

KW - Iodine

KW - Quinoxalines

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Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines

Abstract

Keywords

ASJC Scopus subject areas

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