Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines

Shivaji V. More, M. N.V. Sastry, Chieh Chieh Wang, Ching-Fa Yao

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields using inexpensive, nontoxic, and readily available bench top chemical, iodine in catalytic amount (10 mol %). Besides this, a systematic study was carried out to evaluate parameters such as solvent and catalyst loading. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines, such as substituted phenylene diamines, tetra amines were further subjected to condensation using catalytic amounts of iodine to afford the products in excellent yield.

Original languageEnglish
Pages (from-to)6345-6348
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number37
DOIs
Publication statusPublished - 2005 Sep 12

Fingerprint

Quinoxalines
Diamines
Iodine
Catalysts
Amines
Condensation
Derivatives

Keywords

  • 1,2-Diketones
  • Catalytic amount
  • Ecofriendly process
  • Iodine
  • Quinoxalines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Molecular iodine : A powerful catalyst for the easy and efficient synthesis of quinoxalines. / More, Shivaji V.; Sastry, M. N.V.; Wang, Chieh Chieh; Yao, Ching-Fa.

In: Tetrahedron Letters, Vol. 46, No. 37, 12.09.2005, p. 6345-6348.

Research output: Contribution to journalArticle

More, Shivaji V. ; Sastry, M. N.V. ; Wang, Chieh Chieh ; Yao, Ching-Fa. / Molecular iodine : A powerful catalyst for the easy and efficient synthesis of quinoxalines. In: Tetrahedron Letters. 2005 ; Vol. 46, No. 37. pp. 6345-6348.
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