Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines

Shivaji V. More, M. N.V. Sastry, Chieh Chieh Wang, Ching Fa Yao

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222 Citations (Scopus)


Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields using inexpensive, nontoxic, and readily available bench top chemical, iodine in catalytic amount (10 mol %). Besides this, a systematic study was carried out to evaluate parameters such as solvent and catalyst loading. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines, such as substituted phenylene diamines, tetra amines were further subjected to condensation using catalytic amounts of iodine to afford the products in excellent yield.

Original languageEnglish
Pages (from-to)6345-6348
Number of pages4
JournalTetrahedron Letters
Issue number37
Publication statusPublished - 2005 Sep 12



  • 1,2-Diketones
  • Catalytic amount
  • Ecofriendly process
  • Iodine
  • Quinoxalines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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