Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines

Shivaji V. More, M. N.V. Sastry, Chieh Chieh Wang, Ching Fa Yao

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields using inexpensive, nontoxic, and readily available bench top chemical, iodine in catalytic amount (10 mol %). Besides this, a systematic study was carried out to evaluate parameters such as solvent and catalyst loading. Several aromatic as well as aliphatic 1,2-diketones and aromatic 1,2-diamines, such as substituted phenylene diamines, tetra amines were further subjected to condensation using catalytic amounts of iodine to afford the products in excellent yield.

Original languageEnglish
Pages (from-to)6345-6348
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number37
DOIs
Publication statusPublished - 2005 Sep 12
Externally publishedYes

Keywords

  • 1,2-Diketones
  • Catalytic amount
  • Ecofriendly process
  • Iodine
  • Quinoxalines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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