Modulation of Surface Plasmon Resonance Energy Using Graphene Quantum Dots on Biosensors Application

Early disease detection represents a cornerstone in the diagnostic and detection approaches of contemporary medicine. Biomedical chips offer swift, precise, and cost-effective solutions tailored to specific medical objectives. This research suggests employing graphene quantum dots (GQDs) in conjunction with surface plasmon resonance (SPR) technology to create biochips designed for the rapid identification of pancreatic cancer. In biological research, graphene quantum dots leverage surface plasmon resonance technology to monitor biomolecular interactions. These experiments focus on the immune response to the pancreatic cancer marker Carbohydrate antigen19-9 (CA19-9) protein, leading to the development of biosensors with high sensitivity and accuracy for swift screening processes. This approach enables the detection of minimal changes around 10 Units/mL, achieving a linear regression coefficient of R² = 0.90. Consequently, this detection method allows for the rapid diagnosis of pancreatic cancer and the creation of a specific, fast-screening cancer biosensing chip.