Mitochondrial DNA polymorphisms and the risk of Parkinson's disease in Taiwan

C. M. Chen; C. C. Kuan; G. J. Lee-Chen; Y. R. Wu

doi:10.1007/s00702-007-0658-z

Mitochondrial DNA polymorphisms and the risk of Parkinson's disease in Taiwan

C. M. Chen^*, C. C. Kuan, G. J. Lee-Chen, Y. R. Wu

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A critical role of mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). The association of mitochondrial DNA (mtDNA) polymorphisms 9055G/A, 10398G/A and 13708G/A with PD has been controversial. In this study we analyzed whether these three genetic polymorphisms are associated with PD in a cohort of 416 PD cases and 372 ethnically matched controls. The allele frequency distribution of any of these three analyzed polymorphisms was not significantly different between the cases and the controls. None of the six haplotypes derived influences risk of PD. Notably, after stratification by age, individuals over 70 years of age carrying the haplotype 9055G-10398A-13708G demonstrated a significant decrease in risk of developing PD (OR = 0.44, 95% CI = 0.24-0.80, p = 0.008). These results suggest that the mtDNA haplotype 9055G-10398A-13708G plays a role in PD susceptibility among Taiwanese people older than 70 years of age.

Original language	English
Pages (from-to)	1017-1021
Number of pages	5
Journal	Journal of Neural Transmission
Volume	114
Issue number	8
DOIs	https://doi.org/10.1007/s00702-007-0658-z
Publication status	Published - 2007 Aug

Keywords

Haplotype and disease association
Mitochondrial DNA polymorphisms
Parkinson's disease

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00702-007-0658-z

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@article{57609ba85b474e8dbcbfdcc98c205326,

title = "Mitochondrial DNA polymorphisms and the risk of Parkinson's disease in Taiwan",

abstract = "A critical role of mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). The association of mitochondrial DNA (mtDNA) polymorphisms 9055G/A, 10398G/A and 13708G/A with PD has been controversial. In this study we analyzed whether these three genetic polymorphisms are associated with PD in a cohort of 416 PD cases and 372 ethnically matched controls. The allele frequency distribution of any of these three analyzed polymorphisms was not significantly different between the cases and the controls. None of the six haplotypes derived influences risk of PD. Notably, after stratification by age, individuals over 70 years of age carrying the haplotype 9055G-10398A-13708G demonstrated a significant decrease in risk of developing PD (OR = 0.44, 95% CI = 0.24-0.80, p = 0.008). These results suggest that the mtDNA haplotype 9055G-10398A-13708G plays a role in PD susceptibility among Taiwanese people older than 70 years of age.",

keywords = "Haplotype and disease association, Mitochondrial DNA polymorphisms, Parkinson's disease",

author = "Chen, {C. M.} and Kuan, {C. C.} and Lee-Chen, {G. J.} and Wu, {Y. R.}",

year = "2007",

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T1 - Mitochondrial DNA polymorphisms and the risk of Parkinson's disease in Taiwan

AU - Chen, C. M.

AU - Kuan, C. C.

AU - Lee-Chen, G. J.

AU - Wu, Y. R.

PY - 2007/8

Y1 - 2007/8

N2 - A critical role of mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). The association of mitochondrial DNA (mtDNA) polymorphisms 9055G/A, 10398G/A and 13708G/A with PD has been controversial. In this study we analyzed whether these three genetic polymorphisms are associated with PD in a cohort of 416 PD cases and 372 ethnically matched controls. The allele frequency distribution of any of these three analyzed polymorphisms was not significantly different between the cases and the controls. None of the six haplotypes derived influences risk of PD. Notably, after stratification by age, individuals over 70 years of age carrying the haplotype 9055G-10398A-13708G demonstrated a significant decrease in risk of developing PD (OR = 0.44, 95% CI = 0.24-0.80, p = 0.008). These results suggest that the mtDNA haplotype 9055G-10398A-13708G plays a role in PD susceptibility among Taiwanese people older than 70 years of age.

AB - A critical role of mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). The association of mitochondrial DNA (mtDNA) polymorphisms 9055G/A, 10398G/A and 13708G/A with PD has been controversial. In this study we analyzed whether these three genetic polymorphisms are associated with PD in a cohort of 416 PD cases and 372 ethnically matched controls. The allele frequency distribution of any of these three analyzed polymorphisms was not significantly different between the cases and the controls. None of the six haplotypes derived influences risk of PD. Notably, after stratification by age, individuals over 70 years of age carrying the haplotype 9055G-10398A-13708G demonstrated a significant decrease in risk of developing PD (OR = 0.44, 95% CI = 0.24-0.80, p = 0.008). These results suggest that the mtDNA haplotype 9055G-10398A-13708G plays a role in PD susceptibility among Taiwanese people older than 70 years of age.

KW - Haplotype and disease association

KW - Mitochondrial DNA polymorphisms

KW - Parkinson's disease

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JO - Journal of Neural Transmission

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IS - 8

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Mitochondrial DNA polymorphisms and the risk of Parkinson's disease in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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