Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect

Robert D. Hyldahl; Trevor C. Chen; Kazunori Nosaka

doi:10.1249/JES.0000000000000095

Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect

Robert D. Hyldahl^*, Trevor C. Chen, Kazunori Nosaka

^*Corresponding author for this work

Department of Physical Education and Sport Sciences

Research output: Contribution to journal › Article › peer-review

202 Citations (Scopus)

Abstract

Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.

Original language	English
Pages (from-to)	24-33
Number of pages	10
Journal	Exercise and Sport Sciences Reviews
Volume	45
Issue number	1
DOIs	https://doi.org/10.1249/JES.0000000000000095
Publication status	Published - 2017 Jan 1

Keywords

delayed-onset muscle soreness
eccentric exercise
lengthening contractions
muscle adaptation
muscle damage
muscle soreness
muscle strength

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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AB - Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.

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KW - lengthening contractions

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KW - muscle damage

KW - muscle soreness

KW - muscle strength

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Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect

Abstract

Keywords

ASJC Scopus subject areas

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