Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect

Robert D. Hyldahl*, Trevor C. Chen, Kazunori Nosaka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

180 Citations (Scopus)


Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.

Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalExercise and Sport Sciences Reviews
Issue number1
Publication statusPublished - 2017 Jan 1


  • delayed-onset muscle soreness
  • eccentric exercise
  • lengthening contractions
  • muscle adaptation
  • muscle damage
  • muscle soreness
  • muscle strength

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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