Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect

Robert D. Hyldahl, Chung-Ching Chen, Kazunori Nosaka

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.

Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalExercise and Sport Sciences Reviews
Volume45
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Extracellular Matrix
Skeletal Muscle
Muscles

Keywords

  • delayed-onset muscle soreness
  • eccentric exercise
  • lengthening contractions
  • muscle adaptation
  • muscle damage
  • muscle soreness
  • muscle strength

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect. / Hyldahl, Robert D.; Chen, Chung-Ching; Nosaka, Kazunori.

In: Exercise and Sport Sciences Reviews, Vol. 45, No. 1, 01.01.2017, p. 24-33.

Research output: Contribution to journalArticle

Hyldahl, Robert D. ; Chen, Chung-Ching ; Nosaka, Kazunori. / Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect. In: Exercise and Sport Sciences Reviews. 2017 ; Vol. 45, No. 1. pp. 24-33.
@article{0b5aa7924245426ab0f635c4e5db576b,
title = "Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect",
abstract = "Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.",
keywords = "delayed-onset muscle soreness, eccentric exercise, lengthening contractions, muscle adaptation, muscle damage, muscle soreness, muscle strength",
author = "Hyldahl, {Robert D.} and Chung-Ching Chen and Kazunori Nosaka",
year = "2017",
month = "1",
day = "1",
doi = "10.1249/JES.0000000000000095",
language = "English",
volume = "45",
pages = "24--33",
journal = "Exercise and Sport Sciences Reviews",
issn = "0091-6331",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect

AU - Hyldahl, Robert D.

AU - Chen, Chung-Ching

AU - Nosaka, Kazunori

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.

AB - Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.

KW - delayed-onset muscle soreness

KW - eccentric exercise

KW - lengthening contractions

KW - muscle adaptation

KW - muscle damage

KW - muscle soreness

KW - muscle strength

UR - http://www.scopus.com/inward/record.url?scp=84992391370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992391370&partnerID=8YFLogxK

U2 - 10.1249/JES.0000000000000095

DO - 10.1249/JES.0000000000000095

M3 - Article

VL - 45

SP - 24

EP - 33

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

SN - 0091-6331

IS - 1

ER -