Magnetic susceptibility reduction method for magnetically labeled immunoassay

Chin Yih Hong; C. C. Wu; Y. C. Chiu; S. Y. Yang; H. E. Horng; H. C. Yang

doi:10.1063/1.2206557

Magnetic susceptibility reduction method for magnetically labeled immunoassay

Chin Yih Hong, C. C. Wu, Y. C. Chiu, S. Y. Yang, H. E. Horng^*, H. C. Yang

^*Corresponding author for this work

Undergraduate Program of Electro-Optical Engineering

Research output: Contribution to journal › Article › peer-review

150 Citations (Scopus)

Abstract

In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

Original language	English
Article number	212512
Journal	Applied Physics Letters
Volume	88
Issue number	21
DOIs	https://doi.org/10.1063/1.2206557
Publication status	Published - 2006 May 21

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2206557

Cite this

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title = "Magnetic susceptibility reduction method for magnetically labeled immunoassay",

abstract = "In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.",

author = "Hong, {Chin Yih} and Wu, {C. C.} and Chiu, {Y. C.} and Yang, {S. Y.} and Horng, {H. E.} and Yang, {H. C.}",

note = "Funding Information: This work is supported by National Science Council of Taiwan under Grant Nos. 94-2120-M-003-002, 94-2112-M-003-018, 94-2112-M-003-004, and 94-2212-E-001, and by Ministry of Education, Taiwan, under Grant No. 91-N-FA01-2-4-2.",

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doi = "10.1063/1.2206557",

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T1 - Magnetic susceptibility reduction method for magnetically labeled immunoassay

AU - Hong, Chin Yih

AU - Wu, C. C.

AU - Chiu, Y. C.

AU - Yang, S. Y.

AU - Horng, H. E.

AU - Yang, H. C.

N1 - Funding Information: This work is supported by National Science Council of Taiwan under Grant Nos. 94-2120-M-003-002, 94-2112-M-003-018, 94-2112-M-003-004, and 94-2212-E-001, and by Ministry of Education, Taiwan, under Grant No. 91-N-FA01-2-4-2.

PY - 2006/5/21

Y1 - 2006/5/21

N2 - In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

AB - In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

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Magnetic susceptibility reduction method for magnetically labeled immunoassay

Abstract

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