Magnetic susceptibility reduction method for magnetically labeled immunoassay

Chin Yih Hong, C. C. Wu, Y. C. Chiu, Shieh-Yueh Yang, Herng-Er Horng, Hong-Chang Yang

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

Original languageEnglish
Article number212512
JournalApplied Physics Letters
Volume88
Issue number21
DOIs
Publication statusPublished - 2006 May 21

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immunoassay
magnetic permeability
nanoparticles
marking
fluids

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Magnetic susceptibility reduction method for magnetically labeled immunoassay. / Hong, Chin Yih; Wu, C. C.; Chiu, Y. C.; Yang, Shieh-Yueh; Horng, Herng-Er; Yang, Hong-Chang.

In: Applied Physics Letters, Vol. 88, No. 21, 212512, 21.05.2006.

Research output: Contribution to journalArticle

Hong, Chin Yih ; Wu, C. C. ; Chiu, Y. C. ; Yang, Shieh-Yueh ; Horng, Herng-Er ; Yang, Hong-Chang. / Magnetic susceptibility reduction method for magnetically labeled immunoassay. In: Applied Physics Letters. 2006 ; Vol. 88, No. 21.
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