Magnetic susceptibility reduction method for magnetically labeled immunoassay

Chin Yih Hong, C. C. Wu, Y. C. Chiu, S. Y. Yang, H. E. Horng, H. C. Yang

    Research output: Contribution to journalArticlepeer-review

    135 Citations (Scopus)

    Abstract

    In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established.

    Original languageEnglish
    Article number212512
    JournalApplied Physics Letters
    Volume88
    Issue number21
    DOIs
    Publication statusPublished - 2006 May 21

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

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