Magnetic resonance imaging of hyperpolarized 3He Detected With a High-Tc SQUID in microtesla magnetic field at laboratory environment fields

Hsin Hsien Chen; Hong-Chang Yang; Herng-Er Horng; S. H. Liao; Shieh-Yueh Yang; K. L. Chen; L. M. Wang; M. J. Chen

doi:10.1109/TASC.2010.2084057

Magnetic resonance imaging of hyperpolarized ³He Detected With a High-T_c SQUID in microtesla magnetic field at laboratory environment fields

Hsin Hsien Chen^*, Hong-Chang Yang, Herng-Er Horng, S. H. Liao, Shieh-Yueh Yang, K. L. Chen, L. M. Wang, M. J. Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Nuclear magnetic resonance and imaging (NMR/MRI) of optically pumped (OP) hyperpolarized ³He were studied by using a high-_c SQUID magnetometer device in microtesla magnetic fields. The OP cell was filled with a few milligrams of Rb metal, 0.0798 bar N₂ gas and 0.705 bar ³He gas. The ³He cell had been hyperpolarized at an optical pumping system for 5 ∼ hours first; then it was moved to the SQUID-detected nuclear magnetic resonance and imaging system to measure. An appropriate B₁ pulse level and time duration generated a 5° low flip angle of polarization. The free induction decay NMR signals were measured. The spin-lattice relaxation time (T₁) of ³He was 4.7 hours.We improved the line width of NMR spectrum to 0.8 Hz by compensating the inhomogeneous gradient field of environment. The filtered back projection image of hyperpolarized ³He could show a clear image in one shot. The SQUID-detected NMR/MRI would be a great interest for biological imaging.

Original language	English
Article number	5621847
Pages (from-to)	505-508
Number of pages	4
Journal	IEEE Transactions on Applied Superconductivity
Volume	21
Issue number	3 PART 1
DOIs	https://doi.org/10.1109/TASC.2010.2084057
Publication status	Published - 2011 Jun
Externally published	Yes

Keywords

Flux coupling
Hyperpolarized gas
NMR/MRI
SQUID

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

Access to Document

10.1109/TASC.2010.2084057

Cite this

Chen, H. H., Yang, H-C., Horng, H-E., Liao, S. H., Yang, S-Y., Chen, K. L., Wang, L. M., & Chen, M. J. (2011). Magnetic resonance imaging of hyperpolarized ³He Detected With a High-T_c SQUID in microtesla magnetic field at laboratory environment fields. IEEE Transactions on Applied Superconductivity, 21(3 PART 1), 505-508. Article 5621847. https://doi.org/10.1109/TASC.2010.2084057

Magnetic resonance imaging of hyperpolarized ³He Detected With a High-T_c SQUID in microtesla magnetic field at laboratory environment fields. / Chen, Hsin Hsien; Yang, Hong-Chang; Horng, Herng-Er et al.
In: IEEE Transactions on Applied Superconductivity, Vol. 21, No. 3 PART 1, 5621847, 06.2011, p. 505-508.

Research output: Contribution to journal › Article › peer-review

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abstract = "Nuclear magnetic resonance and imaging (NMR/MRI) of optically pumped (OP) hyperpolarized 3He were studied by using a high-c SQUID magnetometer device in microtesla magnetic fields. The OP cell was filled with a few milligrams of Rb metal, 0.0798 bar N2 gas and 0.705 bar 3He gas. The 3He cell had been hyperpolarized at an optical pumping system for 5 ∼ hours first; then it was moved to the SQUID-detected nuclear magnetic resonance and imaging system to measure. An appropriate B1 pulse level and time duration generated a 5° low flip angle of polarization. The free induction decay NMR signals were measured. The spin-lattice relaxation time (T1) of 3He was 4.7 hours.We improved the line width of NMR spectrum to 0.8 Hz by compensating the inhomogeneous gradient field of environment. The filtered back projection image of hyperpolarized 3He could show a clear image in one shot. The SQUID-detected NMR/MRI would be a great interest for biological imaging.",

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author = "Chen, {Hsin Hsien} and Hong-Chang Yang and Herng-Er Horng and Liao, {S. H.} and Shieh-Yueh Yang and Chen, {K. L.} and Wang, {L. M.} and Chen, {M. J.}",

note = "Funding Information: Manuscript received August 02, 2010; accepted September 28, 2010. Date of publication November 09, 2010; date of current version May 27, 2011. This work is supported by the National Science Council of Taiwan under grant no. 98-2752-M-002-003-PAE.",

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