Magnetic relaxation measurement in immunoassay using high-transition- temperature superconducting quantum interference device system

H. C. Yang; S. Y. Yang; G. L. Fang; W. H. Huang; C. H. Liu; S. H. Liao; H. E. Horng; Chin Yih Hong

doi:10.1063/1.2203390

Magnetic relaxation measurement in immunoassay using high-transition- temperature superconducting quantum interference device system

H. C. Yang^*, S. Y. Yang, G. L. Fang, W. H. Huang, C. H. Liu, S. H. Liao, H. E. Horng, Chin Yih Hong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Due to their ultrahigh sensitivity to magnetic flux, superconducting quantum interference devices (SQUIDs) are able to detect biomagnetic signals. By labeling biotargets with magnetic nanoparticles, several groups have shown that SQUIDs are promising as quantitative probes of biotargets by measuring their magnetic properties. In this work, we describe the design and construction of a high-transition-temperature radio-frequency SQUID magnetometer system for measuring the magnetic relaxation of labeled avidin. We also describe the synthesis of magnetic nanoparticles coated with biotin for use in labeling the avidin. Furthermore, the specifications of the SQUID-based magnetically labeled immunoassay of avidin are explored.

Original language	English
Article number	124701
Journal	Journal of Applied Physics
Volume	99
Issue number	12
DOIs	https://doi.org/10.1063/1.2203390
Publication status	Published - 2006

ASJC Scopus subject areas

General Physics and Astronomy

Access to Document

10.1063/1.2203390

Cite this

@article{68c682df10174dfbb573b435eedecf81,

title = "Magnetic relaxation measurement in immunoassay using high-transition- temperature superconducting quantum interference device system",

abstract = "Due to their ultrahigh sensitivity to magnetic flux, superconducting quantum interference devices (SQUIDs) are able to detect biomagnetic signals. By labeling biotargets with magnetic nanoparticles, several groups have shown that SQUIDs are promising as quantitative probes of biotargets by measuring their magnetic properties. In this work, we describe the design and construction of a high-transition-temperature radio-frequency SQUID magnetometer system for measuring the magnetic relaxation of labeled avidin. We also describe the synthesis of magnetic nanoparticles coated with biotin for use in labeling the avidin. Furthermore, the specifications of the SQUID-based magnetically labeled immunoassay of avidin are explored.",

author = "Yang, {H. C.} and Yang, {S. Y.} and Fang, {G. L.} and Huang, {W. H.} and Liu, {C. H.} and Liao, {S. H.} and Horng, {H. E.} and Hong, {Chin Yih}",

year = "2006",

doi = "10.1063/1.2203390",

language = "English",

volume = "99",

journal = "Journal of Applied Physics",

issn = "0021-8979",

publisher = "American Institute of Physics Publising LLC",

number = "12",

}

TY - JOUR

T1 - Magnetic relaxation measurement in immunoassay using high-transition- temperature superconducting quantum interference device system

AU - Yang, H. C.

AU - Yang, S. Y.

AU - Fang, G. L.

AU - Huang, W. H.

AU - Liu, C. H.

AU - Liao, S. H.

AU - Horng, H. E.

AU - Hong, Chin Yih

PY - 2006

Y1 - 2006

N2 - Due to their ultrahigh sensitivity to magnetic flux, superconducting quantum interference devices (SQUIDs) are able to detect biomagnetic signals. By labeling biotargets with magnetic nanoparticles, several groups have shown that SQUIDs are promising as quantitative probes of biotargets by measuring their magnetic properties. In this work, we describe the design and construction of a high-transition-temperature radio-frequency SQUID magnetometer system for measuring the magnetic relaxation of labeled avidin. We also describe the synthesis of magnetic nanoparticles coated with biotin for use in labeling the avidin. Furthermore, the specifications of the SQUID-based magnetically labeled immunoassay of avidin are explored.

AB - Due to their ultrahigh sensitivity to magnetic flux, superconducting quantum interference devices (SQUIDs) are able to detect biomagnetic signals. By labeling biotargets with magnetic nanoparticles, several groups have shown that SQUIDs are promising as quantitative probes of biotargets by measuring their magnetic properties. In this work, we describe the design and construction of a high-transition-temperature radio-frequency SQUID magnetometer system for measuring the magnetic relaxation of labeled avidin. We also describe the synthesis of magnetic nanoparticles coated with biotin for use in labeling the avidin. Furthermore, the specifications of the SQUID-based magnetically labeled immunoassay of avidin are explored.

UR - http://www.scopus.com/inward/record.url?scp=33745697488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745697488&partnerID=8YFLogxK

U2 - 10.1063/1.2203390

DO - 10.1063/1.2203390

M3 - Article

AN - SCOPUS:33745697488

SN - 0021-8979

VL - 99

JO - Journal of Applied Physics

JF - Journal of Applied Physics

IS - 12

M1 - 124701

ER -

Magnetic relaxation measurement in immunoassay using high-transition- temperature superconducting quantum interference device system

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this