Magnetic relaxation measurement in immunoassay using high-transition- temperature superconducting quantum interference device system

Hong-Chang Yang, Shieh-Yueh Yang, G. L. Fang, W. H. Huang, Chuan-Hsi Liu, Shu-Hsien Liao, Herng-Er Horng, Chin Yih Hong

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Due to their ultrahigh sensitivity to magnetic flux, superconducting quantum interference devices (SQUIDs) are able to detect biomagnetic signals. By labeling biotargets with magnetic nanoparticles, several groups have shown that SQUIDs are promising as quantitative probes of biotargets by measuring their magnetic properties. In this work, we describe the design and construction of a high-transition-temperature radio-frequency SQUID magnetometer system for measuring the magnetic relaxation of labeled avidin. We also describe the synthesis of magnetic nanoparticles coated with biotin for use in labeling the avidin. Furthermore, the specifications of the SQUID-based magnetically labeled immunoassay of avidin are explored.

Original languageEnglish
Article number124701
JournalJournal of Applied Physics
Volume99
Issue number12
DOIs
Publication statusPublished - 2006 Jul 11

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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