Magnetic nano-particles and their applications in immunoassays

H. E. Horng; S. Y. Yang; Chin Yih Hong; H. C. Yang; S. H. Liao; C. M. Liu; C. C. Wu

Magnetic nano-particles and their applications in immunoassays

H. E. Horng^*
, S. Y. Yang
, Chin Yih Hong
, H. C. Yang
, S. H. Liao
, C. M. Liu
, C. C. Wu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe ₃O₄, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.

Original language	English
Pages (from-to)	999-1003
Number of pages	5
Journal	Journal of the Korean Physical Society
Volume	48
Issue number	5 I
Publication status	Published - 2006 May

Keywords

Immunoassay
Magnetic nano-particles
SQUIDs

ASJC Scopus subject areas

General Physics and Astronomy

Cite this

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title = "Magnetic nano-particles and their applications in immunoassays",

abstract = "Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.",

keywords = "Immunoassay, Magnetic nano-particles, SQUIDs",

author = "Horng, \{H. E.\} and Yang, \{S. Y.\} and Hong, \{Chin Yih\} and Yang, \{H. C.\} and Liao, \{S. H.\} and Liu, \{C. M.\} and Wu, \{C. C.\}",

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T1 - Magnetic nano-particles and their applications in immunoassays

AU - Horng, H. E.

AU - Yang, S. Y.

AU - Hong, Chin Yih

AU - Yang, H. C.

AU - Liao, S. H.

AU - Liu, C. M.

AU - Wu, C. C.

PY - 2006/5

Y1 - 2006/5

N2 - Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.

AB - Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.

KW - Immunoassay

KW - Magnetic nano-particles

KW - SQUIDs

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UR - https://www.scopus.com/pages/publications/33745056508#tab=citedBy

M3 - Article

AN - SCOPUS:33745056508

SN - 0374-4884

VL - 48

SP - 999

EP - 1003

JO - Journal of the Korean Physical Society

JF - Journal of the Korean Physical Society

IS - 5 I

ER -

Magnetic nano-particles and their applications in immunoassays

Abstract

Keywords

ASJC Scopus subject areas

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