TY - JOUR
T1 - Magnetic nano-particles and their applications in immunoassays
AU - Horng, H. E.
AU - Yang, S. Y.
AU - Hong, Chin Yih
AU - Yang, H. C.
AU - Liao, S. H.
AU - Liu, C. M.
AU - Wu, C. C.
PY - 2006/5
Y1 - 2006/5
N2 - Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.
AB - Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe 3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.
KW - Immunoassay
KW - Magnetic nano-particles
KW - SQUIDs
UR - http://www.scopus.com/inward/record.url?scp=33745056508&partnerID=8YFLogxK
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M3 - Article
AN - SCOPUS:33745056508
SN - 0374-4884
VL - 48
SP - 999
EP - 1003
JO - Journal of the Korean Physical Society
JF - Journal of the Korean Physical Society
IS - 5 I
ER -